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AB201322

Anti-PXMP2/PMP22 antibody

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Rabbit Polyclonal PXMP2/PMP22 antibody. Suitable for WB and reacts with Human, Rat samples. Immunogen corresponding to Synthetic Peptide within Human PXMP2 aa 1-100.

View Alternative Names

PMP22, PXMP2, Peroxisomal membrane protein 2, 22 kDa peroxisomal membrane protein

1 Images
Western blot - Anti-PXMP2/PMP22 antibody (AB201322)
  • WB

Supplier Data

Western blot - Anti-PXMP2/PMP22 antibody (AB201322)

All lanes:

Western blot - Anti-PXMP2/PMP22 antibody (ab201322)

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A549 whole cell lysate

Lane 2:

PC12 whole cell lysate

Predicted band size: 22 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human PXMP2 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q9NR77

Specificity

Detects endogenous levels of PXMP2/Gbf1 protein.

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Purity is > 95% (by SDS-PAGE).
Storage buffer
pH: 7.3 Preservative: 0.05% Sodium azide Constituents: 99% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The PXMP2/PMP22 protein also known as Peripheral Myelin Protein 22 has an important role in maintaining membrane structures and functions. Its molecular weight is approximately 22 kDa. This protein is mainly found in Peripheral Nervous System (PNS) Schwann cells and to a lesser extent in other tissues. It integrates into the peroxisomal membrane and participates in forming membrane channels that are essential for peroxisomal function. PXMP2/PMP22 influences the structural integrity and permeability of the membrane allowing various small molecules to pass which is essential for maintaining cell homeostasis.
Biological function summary

PXMP2/PMP22 supports the development and maintenance of myelin the protective sheath around nerve fibers that ensures efficient nerve signal transmission. It is an important component of the compact myelin structure. In Schwann cells PXMP2/PMP22 works as part of a complex network of proteins that coordinate to regulate cellular functions necessary for myelin sheath formation and repair. This protein's role in maintaining myelin integrity is integral to the normal functioning of the nervous system.

Pathways

PXMP2/PMP22 is integral to the myelination pathway which involves the assembly and preservation of myelin sheathing nerve fibers. It interacts with other myelin-associated proteins such as Connexin 32 and Myelin Protein Zero. These interactions ensure coordinated development and repair of the myelin sheath which is vital for rapid nerve impulse transmission. Another significant pathway involving PXMP2/PMP22 includes lipid metabolism in which it aids peroxisomal transport processes necessary for breaking down lipid molecules.

PXMP2/PMP22 has connections to Charcot-Marie-Tooth disease type 1A (CMT1A) a hereditary neuropathy characterized by progressive muscle weakness and sensory loss. Alterations in the expression of the PXMP2/PMP22 gene including duplication cause disruptions in normal myelin function leading to the development of CMT1A symptoms. Additionally abnormal PXMP2/PMP22 expression associates with Dejerine-Sottas syndrome revealing its critical role in maintaining myelin integrity. The protein's dysfunction in these diseases further highlights its importance in myelin stability and nerve function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane.
See full target information PXMP2
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