AB228998

Anti-PYROXD2 antibody

Name: Anti-PYROXD2 antibody (ab228998) | Abcam
Brand: Abcam Limited
SKU: AB228998

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(2 Publications)

Rabbit Polyclonal PYROXD2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PYROXD2.

View Alternative Names

C10orf33, PYROXD2, Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PYROXD2 antibody (AB228998)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PYROXD2 antibody (AB228998)

Paraffin-embedded human breast cancer tissue stained for PYROXD2 using ab228998 at 1/500 dilution in immunohistochemical analysis.

Supplier Data

Western blot - Anti-PYROXD2 antibody (AB228998)

7.5% SDS-PAGE gel.

All lanes:

Western blot - Anti-PYROXD2 antibody (ab228998) at 1/1000 dilution

Lane 1:

HEK-293T (human epithelial cell line from embryonic kidney) whole cell lysate at 30 µg

Lane 2:

Raji (Human Burkitt's lymphoma cell line) whole cell lysate at 30 µg

Predicted band size: 63 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PYROXD2. The exact immunogen used to generate this antibody is proprietary information.

Q8N2H3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PYROXD2 also known as Pyridine Nucleotide-Disulfide Oxidoreductase Domain 2 is a protein with a molecular weight of approximately 39 kDa. It functions mechanically as an oxidoreductase enzyme participating in redox reactions by facilitating the transfer of electrons. Expression of PYROXD2 is widespread but shows higher levels in tissues with elevated metabolic activities such as the liver kidney and heart. This widespread expression suggests its fundamental role in cellular processes that require redox homeostasis.

Biological function summary

PYROXD2 contributes to cellular redox balance and detoxification. It operates as part of a larger multi-enzyme complex involved in maintaining oxidative homeostasis in the cell. This function is important for protecting cells against oxidative stress which might lead to cellular damage and apoptosis. By regulating redox-sensitive pathways PYROXD2 helps maintain cellular health and function.

Pathways

PYROXD2 participates in significant biochemical networks focusing on redox regulation and electron transport. Notably the protein interacts within the glutathione metabolic pathway where it works alongside proteins like glutathione peroxidase and glutathione reductase to neutralize reactive oxygen species. PYROXD2 also relates to components of the mitochondrial respiratory chain linking it to important energy-production processes in the cell.

PYROXD2 shows associations with conditions involving oxidative stress including neurodegenerative diseases like Parkinson's Disease. Disrupted redox homeostasis is key in these pathologies where neurons are particularly susceptible to oxidative damage. Additionally PYROXD2 is linked to cardiovascular diseases where oxidative stress contributes to vascular inflammation and damage. These associations point to its potential as a therapeutic target particularly in diseases where oxidative stress plays a critical role.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Probable oxidoreductase that may play a role as regulator of mitochondrial function.

See full target information PYROXD2

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Immune network 23:e34 PubMed37670811

2023

Tumor Promoting Function of DUSP10 in Non-Small Cell Lung Cancer Is Associated With Tumor-Promoting Cytokines.

Applications

Unspecified application

Species

Unspecified reactive species

Xing Wei,Chin Wen Png,Madhushanee Weerasooriya,Heng Li,Chenchen Zhu,Guiping Chen,Chuan Xu,Yongliang Zhang,Xiaohong Xu

International journal of molecular sciences 23: PubMed35055180

2022

Biallelic Variants in Cause a Severe Infantile Metabolic Disorder Affecting Mitochondrial Function.

Applications

Unspecified application

Species

Unspecified reactive species

Nicole J Van Bergen,Daniella H Hock,Lucy Spencer,Sean Massey,Tegan Stait,Zornitza Stark,Sebastian Lunke,Ain Roesley,Heidi Peters,Joy Yaplito Lee,Anna Le Fevre,Oliver Heath,Cristina Mignone,Joseph Yuan-Mou Yang,Monique M Ryan,Colleen D'Arcy,Margot Nash,Sile Smith,Nikeisha J Caruana,David R Thorburn,David A Stroud,Susan M White,John Christodoulou,Natasha J Brown

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-PYROXD2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PYROXD2 antibody (AB228998)

Western blot - Anti-PYROXD2 antibody (AB228998)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

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Product promise