Anti-PYROXD2 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

PYROXD2 also known as Pyridine Nucleotide-Disulfide Oxidoreductase Domain 2 is a protein with a molecular weight of approximately 39 kDa. It functions mechanically as an oxidoreductase enzyme participating in redox reactions by facilitating the transfer of electrons. Expression of PYROXD2 is widespread but shows higher levels in tissues with elevated metabolic activities such as the liver kidney and heart. This widespread expression suggests its fundamental role in cellular processes that require redox homeostasis.

Biological function summary

PYROXD2 contributes to cellular redox balance and detoxification. It operates as part of a larger multi-enzyme complex involved in maintaining oxidative homeostasis in the cell. This function is important for protecting cells against oxidative stress which might lead to cellular damage and apoptosis. By regulating redox-sensitive pathways PYROXD2 helps maintain cellular health and function.

Pathways

PYROXD2 participates in significant biochemical networks focusing on redox regulation and electron transport. Notably the protein interacts within the glutathione metabolic pathway where it works alongside proteins like glutathione peroxidase and glutathione reductase to neutralize reactive oxygen species. PYROXD2 also relates to components of the mitochondrial respiratory chain linking it to important energy-production processes in the cell.

Associated diseases and disorders

PYROXD2 shows associations with conditions involving oxidative stress including neurodegenerative diseases like Parkinson's Disease. Disrupted redox homeostasis is key in these pathologies where neurons are particularly susceptible to oxidative damage. Additionally PYROXD2 is linked to cardiovascular diseases where oxidative stress contributes to vascular inflammation and damage. These associations point to its potential as a therapeutic target particularly in diseases where oxidative stress plays a critical role.