AB122718

Anti-PZP antibody

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(2 Publications)

Rabbit Polyclonal PZP antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PZP aa 400-500.

View Alternative Names

CPAMD6, PZP, Pregnancy zone protein, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PZP antibody (AB122718)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PZP antibody (AB122718)

ab122718, at 1/10 dilution, staining PZP in paraffin-embedded Human pancreas tissue by Immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PZP aa 400-500. The exact immunogen used to generate this antibody is proprietary information.

P20742

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/10 - 1/20", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PZP also known as Pregnancy Zone Protein is a critical glycoprotein with a molecular weight of approximately 360 kDa. It is mainly expressed in the liver but also found in the blood plasma particularly during pregnancy. PZP is similar in structure to alpha-2-macroglobulin and functions by inhibiting proteases. This protein binds and inactivates various proteinases showing its role in modulating enzymatic activity in the bloodstream.

Biological function summary

PZP contributes to immune response modulation during pregnancy by forming complexes with proteinases. These complexes prevent the degradation of other proteins helping to protect the fetus and maintain maternal immune tolerance. PZP exists as a tetramer in its active form allowing it to effectively trap and neutralize proteinases. Its expression levels rise significantly during pregnancy indicating its role in maternal adaptation.

Pathways

PZP is involved in the regulation of inflammation and the immune response. It participates in the acute phase response pathway which involves proteins like alpha-2-macroglobulin and C-reactive protein. By binding to various cytokines and growth factors PZP helps control inflammatory processes and cellular communication maintaining tissue homeostasis. These interactions show how PZP plays a role in protecting against excessive inflammation.

Researchers have linked PZP to conditions like Alzheimer's disease and cancer. In Alzheimer's PZP might interact with amyloid-beta peptides similar to alpha-2-macroglobulin hinting at a protective role against plaque formation. In cancer PZP's interaction with proteases suggests a role in tumor progression and metastasis. Understanding these links could help in developing therapeutic strategies targeting protease activity in these diseases.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

See full target information PZP

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

European journal of haematology 106:221-229 PubMed33098696

2020

RLTPR Q575E: A novel recurrent gain-of-function mutation in patients with adult T-cell leukemia/lymphoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yuichiro Uchida,Makoto Yoshimitsu,Miho Hachiman,Shuichi Kusano,Naosuke Arima,Kodai Shima,Maiko Hayashida,Yuhei Kamada,Daisuke Nakamura,Akihiko Arai,Yuetsu Tanaka,Hiromitsu Hara,Kenji Ishitsuka

Experimental eye research 172:21-29 PubMed29580721

2018

Quantitative analysis of hydroxyapatite-binding plasma proteins in genotyped individuals with late-stage age-related macular degeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Swati Arya,Eszter Emri,Silvia A Synowsky,Sally L Shirran,Neda Barzegar-Befroei,Tunde Peto,Catherine H Botting,Imre Lengyel,Alan J Stewart

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-PZP antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PZP antibody (AB122718)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

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