AB233166

Anti-PZP antibody

Name: Anti-PZP antibody (ab233166) | Abcam
Brand: Abcam Limited
SKU: AB233166
Price: 525 USD
Availability: InStock

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(4 Publications)

Rabbit Polyclonal PZP antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PZP aa 1200-1400.

View Alternative Names

CPAMD6, PZP, Pregnancy zone protein, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6

8 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PZP antibody (AB233166)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PZP antibody (AB233166)

Formalin-fixed, paraffin-embedded human stomach cancer tissue stained for PZP using ab233166 at 20 μg/ml in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PZP antibody (AB233166)

Formalin-fixed, paraffin-embedded human prostate cancer tissue stained for PZP using ab233166 at 20 μg/ml in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PZP antibody (AB233166)

Formalin-fixed, paraffin-embedded human cerebrum tissue stained for PZP using ab233166 at 20 μg/ml in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PZP antibody (AB233166)

Formalin-fixed, paraffin-embedded human glioma tissue stained for PZP using ab233166 at 20 μg/ml in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PZP antibody (AB233166)

Formalin-fixed, paraffin-embedded human stomach tissue stained for PZP using ab233166 at 20 μg/ml in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PZP antibody (AB233166)

Formalin-fixed, paraffin-embedded human liver tissue stained for PZP using ab233166 at 20 μg/ml in immunohistochemical analysis.

Supplier Data

Western blot - Anti-PZP antibody (AB233166)

All lanes:

Western blot - Anti-PZP antibody (ab233166) at 2 µg/mL

Lane 1:

Human serum

Lane 2:

Human lung tissue lysate

Predicted band size: 164 kDa

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Supplier Data

Western blot - Anti-PZP antibody (AB233166)

All lanes:

Western blot - Anti-PZP antibody (ab233166) at 2 µg/mL

All lanes:

Recombinant human PZP

Predicted band size: 164 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human PZP aa 1200-1400. The exact immunogen used to generate this antibody is proprietary information.

P20742

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

Antigen-specific affinity chromatography followed by Protein A affinity chromatography.

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PZP also known as Pregnancy Zone Protein is a critical glycoprotein with a molecular weight of approximately 360 kDa. It is mainly expressed in the liver but also found in the blood plasma particularly during pregnancy. PZP is similar in structure to alpha-2-macroglobulin and functions by inhibiting proteases. This protein binds and inactivates various proteinases showing its role in modulating enzymatic activity in the bloodstream.

Biological function summary

PZP contributes to immune response modulation during pregnancy by forming complexes with proteinases. These complexes prevent the degradation of other proteins helping to protect the fetus and maintain maternal immune tolerance. PZP exists as a tetramer in its active form allowing it to effectively trap and neutralize proteinases. Its expression levels rise significantly during pregnancy indicating its role in maternal adaptation.

Pathways

PZP is involved in the regulation of inflammation and the immune response. It participates in the acute phase response pathway which involves proteins like alpha-2-macroglobulin and C-reactive protein. By binding to various cytokines and growth factors PZP helps control inflammatory processes and cellular communication maintaining tissue homeostasis. These interactions show how PZP plays a role in protecting against excessive inflammation.

Researchers have linked PZP to conditions like Alzheimer's disease and cancer. In Alzheimer's PZP might interact with amyloid-beta peptides similar to alpha-2-macroglobulin hinting at a protective role against plaque formation. In cancer PZP's interaction with proteases suggests a role in tumor progression and metastasis. Understanding these links could help in developing therapeutic strategies targeting protease activity in these diseases.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

See full target information PZP

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Clinical proteomics 22:12 PubMed40229672

2025

Proteomic profiles screening identified novel exosomal protein biomarkers for diagnosis of lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Weiyan Feng,Ying Lin,Ling Zhang,Weiming Hu

Biomedicines 11: PubMed37509617

2023

Pregnancy Zone Protein Serves as a Prognostic Marker and Favors Immune Infiltration in Lung Adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Kehong Chen,Taihao Zheng,Cai Chen,Liangzhong Liu,Zhengjun Guo,Yuan Peng,Xiaoyue Zhang,Zhenzhou Yang

Clinical epigenetics 15:73 PubMed37120619

2023

Epigenetic reactivation of tumor suppressor genes with CRISPRa technologies as precision therapy for hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Agustin Sgro,Joseph Cursons,Charlene Waryah,Eleanor A Woodward,Momeneh Foroutan,Ruqian Lyu,George C T Yeoh,Peter J Leedman,Pilar Blancafort

International journal of molecular sciences 24: PubMed36674967

2023

Diclofenac Disrupts the Circadian Clock and through Complex Cross-Talks Aggravates Immune-Mediated Liver Injury-A Repeated Dose Study in Minipigs for 28 Days.

Applications

Unspecified application

Species

Unspecified reactive species

Saravanakumar Selvaraj,Jung-Hwa Oh,Seokjoo Yoon,Jürgen Borlak

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-PZP antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PZP antibody (AB233166)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PZP antibody (AB233166)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PZP antibody (AB233166)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PZP antibody (AB233166)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PZP antibody (AB233166)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PZP antibody (AB233166)

Western blot - Anti-PZP antibody (AB233166)

Western blot - Anti-PZP antibody (AB233166)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

Product promise