Rabbit Polyclonal QDPR/DHPR antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human QDPR aa 1 to C-terminus.
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- Cellular and molecular life sciences : CMLS 79:5532022A plant-based mutant huntingtin model-driven discovery of impaired expression of GTPCH and DHFR.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChiu-Yueh Hung,Chuanshu Zhu,Farooqahmed S Kittur,Maotao He,Erland Arning,Jianhui Zhang,Asia J Johnson,Gurpreet S Jawa,Michelle D Thomas,Tomas T Ding,Jiahua XiePubMed 36251090
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human QDPR aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link P09417
Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Human | Tested | Tested |
| Mouse | Tested | Expected |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100.00000 - 1/500.00000 | Notes Perform antigen retrieval using heat mediated 10mM Citrate buffer(pH6.0) or Tris-EDTA buffer (pH8.0) |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
Associated Products
Select an associated product type
2 products for Alternative Product
Target data
Function
Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin.
Alternative names
DHPR, SDR33C1, QDPR, Dihydropteridine reductase, HDHPR, Quinoid dihydropteridine reductase, Short chain dehydrogenase/reductase family 33C member 1
Recommended products
Rabbit Polyclonal QDPR/DHPR antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human QDPR aa 1 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human QDPR aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link P09417
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
QDPR also known as Quinoid Dihydropteridine Reductase or DHPR is an enzyme that plays an important role in tetrahydrobiopterin (BH4) regeneration. It has a molecular mass of approximately 25 kDa and is found in various tissues such as the liver and brain where it contributes to neurotransmitter synthesis and other physiological processes. The DHPR protein is encoded by the QDPR gene in humans and is highly conserved across species indicating its essential function.
- Biological function summary
QDPR catalyzes the reduction of quinonoid dihydrobiopterin (qBH2) to tetrahydrobiopterin maintaining BH4 homeostasis. This process supports neurotransmitter synthesis by replenishing BH4 a cofactor for aromatic amino acid hydroxylases. QDPR does not operate as part of a large multi-protein complex but has a significant role as a standalone enzyme that assists hydroxylating enzymes important for dopamine serotonin and nitric oxide production.
- Pathways
QDPR contributes to the biosynthesis of catecholamines and serotonin both essential neurotransmitter pathways. It supports phenylalanine hydroxylase tyrosine hydroxylase and tryptophan hydroxylase activities by sustaining BH4 levels. These pathways are integral to proper neurological function and are tightly regulated due to their dependence on QDPR's enzymatic activity. The function of QDPR aligns with the regulation of neurotransmitter metabolism working alongside other critical proteins in these pathways.
- Associated diseases and disorders
QDPR deficiency can result in hyperphenylalaninemia a condition characterized by elevated phenylalanine levels leading to cognitive impairments. This deficiency affects neurotransmitter synthesis linking it to neurological diseases such as depressive disorders. Additionally QDPR-related disruptions can implicate other proteins like phenylalanine hydroxylase showing how these metabolic pathways and their components are interwoven into broader physiological contexts.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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3 product images
Western blot - Anti-QDPR/DHPR antibody (ab126150)
12% SDS PAGE
All lanes: Western blot - Anti-QDPR/DHPR antibody (ab126150) at 1/1000 dilution
All lanes: Mouse liver whole cell lysate at 50 µg
Predicted band size: 26 kDa, 29 kDa, 30 kDa
Western blot - Anti-QDPR/DHPR antibody (ab126150)
12% SDS PAGE
All lanes: Western blot - Anti-QDPR/DHPR antibody (ab126150) at 1/1000 dilution
All lanes: Jurkat whole cell lysate at 30 µg
Predicted band size: 26 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-QDPR/DHPR antibody (ab126150)
ab126150, at 1/500 dilution, staining QDPR/DHPR in Formalin-fixed, Paraffin-embedded Human Colon cancer tissue by Immunohistochemistry.
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