AB232983

Anti-QDPR/DHPR antibody

Name: Anti-QDPR/DHPR antibody (ab232983) | Abcam
Brand: Abcam Limited
SKU: AB232983
Price: 525 USD
Availability: InStock

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(3 Publications)

Rabbit Polyclonal QDPR/DHPR antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Recombinant fragment - Human, Rat, Pig, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human QDPR.

View Alternative Names

DHPR, SDR33C1, QDPR, Dihydropteridine reductase, HDHPR, Quinoid dihydropteridine reductase, Short chain dehydrogenase/reductase family 33C member 1

4 Images

Immunocytochemistry/ Immunofluorescence - Anti-QDPR/DHPR antibody (AB232983)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-QDPR/DHPR antibody (AB232983)

HepG2 (human liver hepatocellular carcinoma cell line) cells labelling QDPR/DHPR (green) using ab232983 at 20 ug/ml in ICC/IF. FITC staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-QDPR/DHPR antibody (AB232983)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-QDPR/DHPR antibody (AB232983)

Formalin-fixed, paraffin-embedded human cerebrum tissue stained for QDPR/DHPR using ab232983 at 20ug/ml in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-QDPR/DHPR antibody (AB232983)

All lanes:

Western blot - Anti-QDPR/DHPR antibody (ab232983) at 2 µg/mL

Lane 1:

HepG2 (human liver hepatocellular carcinoma cell line) cell lysate.

Lane 2:

Pig liver tissue lysate

Lane 3:

Pig brain tissue lysate.

Lane 4:

Rat brain tissue lysate.

Secondary

All lanes:

HRP-Linked Guinea pig Anti-Rabbit Ab at 1/2000 dilution

Predicted band size: 26 kDa

false

Supplier Data

Western blot - Anti-QDPR/DHPR antibody (AB232983)

All lanes:

Western blot - Anti-QDPR/DHPR antibody (ab232983) at 2 µg/mL

All lanes:

Recombinant human QDPR/DHPR protein

Predicted band size: 26 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat, Human, Pig

Applications

WB, IHC-P, ICC/IF

applications

Immunogen

Recombinant Full Length Protein corresponding to Human QDPR.

P09417

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/5 - 1/20", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Recombinant fragment - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

Antigen-specific affinity chromatography followed by Protein A affinity chromatography.

Storage buffer

pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

QDPR also known as Quinoid Dihydropteridine Reductase or DHPR is an enzyme that plays an important role in tetrahydrobiopterin (BH4) regeneration. It has a molecular mass of approximately 25 kDa and is found in various tissues such as the liver and brain where it contributes to neurotransmitter synthesis and other physiological processes. The DHPR protein is encoded by the QDPR gene in humans and is highly conserved across species indicating its essential function.

Biological function summary

QDPR catalyzes the reduction of quinonoid dihydrobiopterin (qBH2) to tetrahydrobiopterin maintaining BH4 homeostasis. This process supports neurotransmitter synthesis by replenishing BH4 a cofactor for aromatic amino acid hydroxylases. QDPR does not operate as part of a large multi-protein complex but has a significant role as a standalone enzyme that assists hydroxylating enzymes important for dopamine serotonin and nitric oxide production.

Pathways

QDPR contributes to the biosynthesis of catecholamines and serotonin both essential neurotransmitter pathways. It supports phenylalanine hydroxylase tyrosine hydroxylase and tryptophan hydroxylase activities by sustaining BH4 levels. These pathways are integral to proper neurological function and are tightly regulated due to their dependence on QDPR's enzymatic activity. The function of QDPR aligns with the regulation of neurotransmitter metabolism working alongside other critical proteins in these pathways.

QDPR deficiency can result in hyperphenylalaninemia a condition characterized by elevated phenylalanine levels leading to cognitive impairments. This deficiency affects neurotransmitter synthesis linking it to neurological diseases such as depressive disorders. Additionally QDPR-related disruptions can implicate other proteins like phenylalanine hydroxylase showing how these metabolic pathways and their components are interwoven into broader physiological contexts.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin.

See full target information QDPR

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Evidence-based complementary and alternative medicine : eCAM 2022:7464893 PubMed36452141

2022

NBP Relieves Cardiac Injury and Reduce Oxidative Stress and Cell Apoptosis in Heart Failure Mice by Activating Nrf2/HO-1/Ca-SERCA2a Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Zhongyu Wang,Yan Zhang,Lei Wang,Chun Yang,Hongliang Yang

eLife 11: PubMed35293859

2022

The TFIIH complex is required to establish and maintain mitotic chromosome structure.

Applications

Unspecified application

Species

Unspecified reactive species

Julian Haase,Richard Chen,Wesley M Parker,Mary Kate Bonner,Lisa M Jenkins,Alexander E Kelly

Oxidative medicine and cellular longevity 2021:7328437 PubMed34373768

2021

Opioid Receptor Agonist Inhibits Myocardial Injury in Heart Failure Rats through Activating Nrf2/HO-1 Pathway and Regulating Ca-SERCA2a.

Applications

Unspecified application

Species

Unspecified reactive species

Tengfei Wu,Hui Yao,Binghua Zhang,Shenglai Zhou,Ping Hou,Keyan Chen

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-QDPR/DHPR antibody

Immunocytochemistry/ Immunofluorescence - Anti-QDPR/DHPR antibody (AB232983)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-QDPR/DHPR antibody (AB232983)

Western blot - Anti-QDPR/DHPR antibody (AB232983)

Western blot - Anti-QDPR/DHPR antibody (AB232983)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

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Assay Kits

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

Product promise