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AB122807

Anti-QIL1 antibody

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(1 Publication)

Rabbit Polyclonal QIL1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MICOS13 aa 1 to C-terminus.

View Alternative Names

C19orf70, MIC13, QIL1, MICOS13, MICOS complex subunit MIC13, Protein P117

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-QIL1 antibody (AB122807)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-QIL1 antibody (AB122807)

Immunofluorescent staining of Human cell line A-431 shows positivity in mitochondria. Recommended concentration of ab122807 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-QIL1 antibody (AB122807)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-QIL1 antibody (AB122807)

ab122807, at 1/10 dilution, staining QIL1 in paraffin-embedded Human stomach tissue by Immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human MICOS13 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q5XKP0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/10 - 1/20", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

QIL1 also known as MICOS complex subunit MIC13 is a protein that plays a mechanical role in mitochondrial function. The Mass of QIL1 is approximately 12 kDa. It is extensively expressed in various tissues indicating a broad functional significance. QIL1 is a component of the MICOS complex which is vital for maintaining the structure of mitochondrial cristae. QIL1 contributes to the formation and stabilization of these structural features within mitochondria.
Biological function summary

QIL1 supports the integrity and function of mitochondrial inner membranes. It is involved in the MICOS complex a critical multi-protein assembly ensuring proper mitochondrial architecture. This complex contributes to processes like energy production and apoptosis by preserving the cristae structure. It also interacts with other proteins in the complex such as MIC10 and MIC60 to perform its tasks efficiently. QIL1's stable expression across tissues reflects its essential role in mitochondrial health and cellular metabolism.

Pathways

The involvement of QIL1 ensures the smooth operation of mitochondria-related pathways specifically oxidative phosphorylation and apoptosis. In oxidative phosphorylation its role helps maintain efficient ATP production within the electron transport chain where several proteins conduct electron flow and energy conversion. In apoptosis QIL1 assists in regulating the release of cytochrome c a process essential for controlled cell death which is facilitated by proteins like BCL-2 family.

Proper function of QIL1 is linked to mitochondrial encephalopathy and cardiomyopathy. Disruptions in QIL1 lead to dysfunctions in mitochondrial architecture which may contribute to neurodegenerative diseases like Leigh syndrome. Its association with structural mitochondrial integrity connects it to complex I deficiency often linked to MICOS-related proteins. The lack of QIL1 function results in compromised cellular energetics highlighting its critical role in disease states involving mitochondrial malfunction.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed : 25997101, PubMed : 27623147, PubMed : 32567732). Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology (PubMed : 25997101, PubMed : 27623147, PubMed : 32567732). Required for the incorporation of MICOS10/MIC10 into the MICOS complex (PubMed : 25997101, PubMed : 27623147).
See full target information MICOS13
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cytogenetic and genome research 161:167-177 PubMed33951625

2021

Mus musculus Barrier-To-Autointegration Factor 2 (Banf2) is Not Essential for Spermatogenesis or Fertility.

Applications

Unspecified application

Species

Unspecified reactive species

Chang-Min Niu,Meng-Meng Xia,Ya-Nan Zhong,Ying Zheng
View all publications
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Product promise

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