Rabbit Polyclonal QSOX2 antibody. C-terminal. Suitable for IP, WB and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human QSOX2 aa 600 to C-terminus.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7 - 8
Preservative: 0.09% Sodium azide
Constituents: 99% Tris citrate/phosphate- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human QSOX2 aa 600 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q6ZRP7
Reactivity data
Select an application| IP | WB | |
|---|---|---|
| Human | Tested | Tested |
| Chimpanzee | Predicted | Predicted |
| Cynomolgus monkey | Predicted | Predicted |
| Orangutan | Predicted | Predicted |
| Rhesus monkey | Predicted | Predicted |
IP
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 2.00000-10.00000 µg/mg of lysate | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Chimpanzee, Cynomolgus monkey, Rhesus monkey, Orangutan | Dilution info - | Notes - |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/2500.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Chimpanzee, Cynomolgus monkey, Rhesus monkey, Orangutan | Dilution info - | Notes - |
Associated Products
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Target data
Function
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis.
Alternative names
QSCN6L1, SOXN, QSOX2, Sulfhydryl oxidase 2, Neuroblastoma-derived sulfhydryl oxidase, Quiescin Q6-like protein 1
Recommended products
Rabbit Polyclonal QSOX2 antibody. C-terminal. Suitable for IP, WB and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human QSOX2 aa 600 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7 - 8
Preservative: 0.09% Sodium azide
Constituents: 99% Tris citrate/phosphate- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human QSOX2 aa 600 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q6ZRP7
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
QSOX2 also known as Quiescin Sulfhydryl Oxidase 2 is an enzyme that catalyzes the formation of disulfide bonds essential for protein folding. It belongs to a family of sulfhydryl oxidases and has a molecular mass of approximately 82 kDa. This protein functions in the endoplasmic reticulum where enhancing oxidative folding in proteins occurs. QSOX2 exhibits expression in various tissues but it is especially found in fetal liver pancreas and placenta.
- Biological function summary
QSOX2 contributes to protein folding by promoting protein stability through disulfide bond formation. This protein is not known to be part of a larger complex but its activity supports the homeostasis within the endoplasmic reticulum. By ensuring proper protein folding QSOX2 prevents accumulation of misfolded proteins that could be detrimental to cellular functions. Stability in protein architecture is pivotal for maintaining cellular integrity and health.
- Pathways
QSOX2 plays an important role in the protein processing in the endoplasmic reticulum (ER) pathway. This pathway ensures proteins achieve their correct three-dimensional structures for functionality. Additionally QSOX2 may influence oxidative stress response pathways by maintaining redox balance in the ER. Within these pathways QSOX2 is related to proteins such as Protein Disulfide Isomerase that also assist in disulfide bond formation and proper protein folding within the ER.
- Associated diseases and disorders
QSOX2 may have implications in certain pathological conditions including cancer and neurodegeneration. Aberrant expression of QSOX2 has been linked to tumor progression where its increased activity may support cancer cell survival and proliferation by ensuring proper protein folding and reducing ER stress. In neurodegenerative disorders links between QSOX2 and proteins like amyloid precursor protein suggest potential roles in the accumulation of misfolded proteins leading to cellular dysfunction in these diseases.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-QSOX2 antibody - C-terminal (ab191168)
Lysates prepared using RIPA lysis buffer.
All lanes: Western blot - Anti-QSOX2 antibody - C-terminal (ab191168) at 1 µg/mL
Lane 1: HeLa whole cell lysate at 50 µg
Lane 2: 293T whole cell lysate at 50 µg
Lane 3: Jurkat whole cell lysate at 50 µg
Developed using the ECL technique.
Predicted band size: 78 kDa
Exposure time: 3min
Immunoprecipitation - Anti-QSOX2 antibody - C-terminal (ab191168)
Detection of QSOX2 in immunoprecipitates of HeLa whole cell lysate prepared using RIPA lysis buffer (1 mg for IP, 20% of IP loaded) using ab191168 at 6 μg/mg lysate for IP and at 1 μg/ml for subsequent Western blot detection (Lane 1). Lane 2 represents control IgG IP.
Detection: Chemiluminescence with an exposure time of 3 minutes.All lanes: Immunoprecipitation - Anti-QSOX2 antibody - C-terminal (ab191168)
Predicted band size: 78 kDa
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