JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB191168

Anti-QSOX2 antibody - C-terminal

Be the first to review this product! Submit a review

|

(0 Publication)

Rabbit Polyclonal QSOX2 antibody. C-terminal. Suitable for IP, WB and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human QSOX2 aa 600 to C-terminus.

View Alternative Names

QSCN6L1, SOXN, QSOX2, Sulfhydryl oxidase 2, Neuroblastoma-derived sulfhydryl oxidase, Quiescin Q6-like protein 1

2 Images
Western blot - Anti-QSOX2 antibody - C-terminal (AB191168)
  • WB

Supplier Data

Western blot - Anti-QSOX2 antibody - C-terminal (AB191168)

Lysates prepared using RIPA lysis buffer.

All lanes:

Western blot - Anti-QSOX2 antibody - C-terminal (ab191168) at 1 µg/mL

Lane 1:

HeLa whole cell lysate at 50 µg

Lane 2:

293T whole cell lysate at 50 µg

Lane 3:

Jurkat whole cell lysate at 50 µg

Predicted band size: 78 kDa

true

Exposure time: 3min

Immunoprecipitation - Anti-QSOX2 antibody - C-terminal (AB191168)
  • IP

Supplier Data

Immunoprecipitation - Anti-QSOX2 antibody - C-terminal (AB191168)

Detection of QSOX2 in immunoprecipitates of HeLa whole cell lysate prepared using RIPA lysis buffer (1 mg for IP, 20% of IP loaded) using ab191168 at 6 μg/mg lysate for IP and at 1 μg/ml for subsequent Western blot detection (Lane 1). Lane 2 represents control IgG IP.
Detection : Chemiluminescence with an exposure time of 3 minutes.

All lanes:

Immunoprecipitation - Anti-QSOX2 antibody - C-terminal (ab191168)

Predicted band size: 78 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IP, WB

applications

Immunogen

Synthetic Peptide within Human QSOX2 aa 600 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q6ZRP7

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-10 µg/mg of lysate", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2500", "WB-species-notes": "<p></p>" }, "Chimpanzee": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cynomolgus monkey": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
style
left-column
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: 99% Tris citrate/phosphate
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

QSOX2 also known as Quiescin Sulfhydryl Oxidase 2 is an enzyme that catalyzes the formation of disulfide bonds essential for protein folding. It belongs to a family of sulfhydryl oxidases and has a molecular mass of approximately 82 kDa. This protein functions in the endoplasmic reticulum where enhancing oxidative folding in proteins occurs. QSOX2 exhibits expression in various tissues but it is especially found in fetal liver pancreas and placenta.
Biological function summary

QSOX2 contributes to protein folding by promoting protein stability through disulfide bond formation. This protein is not known to be part of a larger complex but its activity supports the homeostasis within the endoplasmic reticulum. By ensuring proper protein folding QSOX2 prevents accumulation of misfolded proteins that could be detrimental to cellular functions. Stability in protein architecture is pivotal for maintaining cellular integrity and health.

Pathways

QSOX2 plays an important role in the protein processing in the endoplasmic reticulum (ER) pathway. This pathway ensures proteins achieve their correct three-dimensional structures for functionality. Additionally QSOX2 may influence oxidative stress response pathways by maintaining redox balance in the ER. Within these pathways QSOX2 is related to proteins such as Protein Disulfide Isomerase that also assist in disulfide bond formation and proper protein folding within the ER.

QSOX2 may have implications in certain pathological conditions including cancer and neurodegeneration. Aberrant expression of QSOX2 has been linked to tumor progression where its increased activity may support cancer cell survival and proliferation by ensuring proper protein folding and reducing ER stress. In neurodegenerative disorders links between QSOX2 and proteins like amyloid precursor protein suggest potential roles in the accumulation of misfolded proteins leading to cellular dysfunction in these diseases.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis.
See full target information QSOX2
style
left-column
style
left-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
style
left-column
style
right-column

Associated Products

Select an associated product type
Alternative Product
Primary Antibodies

AB121376

Anti-QSOX2 antibody

primary-antibodies

qsox2-antibody-ab121376

5

(1 reviews)

style
bg-slate-100

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com