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Rabbit Polyclonal CADH4 antibody. Suitable for IHC-P and reacts with Mouse samples. Immunogen corresponding to Recombinant Fragment Protein within Human Cadherin-4.

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Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-R Cadherin antibody (AB227153), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 79.99% PBS, 20% Glycerol (glycerin, glycerine)

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human Cadherin-4. The exact immunogen used to generate this antibody is proprietary information. Database link P55283

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-P
Human
Predicted
Mouse
Tested
Chicken
Predicted

Tested
Tested

Species

Mouse

Dilution info

1/100.00000 - 1/1000.00000

Notes

-

Predicted
Predicted

Species

Chicken, Human

Dilution info

-

Notes

-

Associated Products

Select an associated product type

1 product for Alternative Product

Target data

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.

Alternative names

Recommended products

Rabbit Polyclonal CADH4 antibody. Suitable for IHC-P and reacts with Mouse samples. Immunogen corresponding to Recombinant Fragment Protein within Human Cadherin-4.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human Cadherin-4. The exact immunogen used to generate this antibody is proprietary information. Database link P55283
Purification technique

Affinity purification Immunogen

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

R Cadherin also known as Cadherin-4 or CDH4 is a classical cadherin that plays a role in calcium-dependent cell-cell adhesion. This protein weighs approximately 90 kDa. It expresses in neural tissues particularly within the developing central nervous system as well as in the retina and certain epithelial tissues. R Cadherin is a member of the cadherin superfamily which comprises proteins responsible for mediating cell-cell adhesion in a variety of tissues.

Biological function summary

This protein contributes to the regulation of cell adhesion and tissue morphogenesis. R Cadherin mediates homophilic interactions which means it binds to the same molecule on adjacent cells to maintain tissue architecture. It often forms a complex with catenins which link cadherins to the actin cytoskeleton. This interaction influences cell polarity migration and tissue maintenance impacting the development and maintenance of the nervous system and the eye.

Pathways

Many scientific studies place R Cadherin in the Wnt signaling pathway where it influences cellular proliferation and differentiation. It shows interaction with other cadherins like N-Cadherin part of the same superfamily each playing distinct roles in development processes by modulating cell adhesion properties important for proper pathway functioning. The protein interactions in these pathways help explain its role in cellular development and homeostasis.

Associated diseases and disorders

Scientists have associated R Cadherin with cancer and retinal disorders. Aberrant expression or dysfunction of this protein can disrupt normal cell adhesion which can lead to tumor progression and metastasis. Furthermore it interacts with proteins like beta-catenin involved in both Wnt signaling and oncogenesis. Alterations in R Cadherin expression also relate to certain retinal degenerative diseases emphasizing its importance in maintaining structured tissue integrity and signaling.

Product promise

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1 product image

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-R Cadherin antibody (ab227153), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-R Cadherin antibody (ab227153)

    Paraffin embedded mouse duodenum tissue stained for R Cadherin with ab227153 (1/500 dilution) in immunohistochemical analysis.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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