AB109242

Anti-R Cadherin antibody [EPR4836]

RabMAb
Recombinant
What is this?

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(3 Publications)

Rabbit Recombinant Monoclonal CADH4 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications.

View Alternative Names

Cadherin-4, Retinal cadherin, R-CAD, R-cadherin, CDH4

1 Images

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Western blot - Anti-R Cadherin antibody [EPR4836] (AB109242)

All lanes:

Western blot - Anti-R Cadherin antibody [EPR4836] (ab109242) at 1/10000 dilution

Lane 1:

HepG2 cell lysate at 10 µg/mL

Lane 2:

Fetal brain lysate at 10 µg/mL

Lane 3:

SH-SY5Y cell lysate at 10 µg/mL

Predicted band size: 100 kDa

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Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR4836

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Stable for 12 months at -20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

R Cadherin also known as Cadherin-4 or CDH4 is a classical cadherin that plays a role in calcium-dependent cell-cell adhesion. This protein weighs approximately 90 kDa. It expresses in neural tissues particularly within the developing central nervous system as well as in the retina and certain epithelial tissues. R Cadherin is a member of the cadherin superfamily which comprises proteins responsible for mediating cell-cell adhesion in a variety of tissues.

Biological function summary

This protein contributes to the regulation of cell adhesion and tissue morphogenesis. R Cadherin mediates homophilic interactions which means it binds to the same molecule on adjacent cells to maintain tissue architecture. It often forms a complex with catenins which link cadherins to the actin cytoskeleton. This interaction influences cell polarity migration and tissue maintenance impacting the development and maintenance of the nervous system and the eye.

Pathways

Many scientific studies place R Cadherin in the Wnt signaling pathway where it influences cellular proliferation and differentiation. It shows interaction with other cadherins like N-Cadherin part of the same superfamily each playing distinct roles in development processes by modulating cell adhesion properties important for proper pathway functioning. The protein interactions in these pathways help explain its role in cellular development and homeostasis.

Scientists have associated R Cadherin with cancer and retinal disorders. Aberrant expression or dysfunction of this protein can disrupt normal cell adhesion which can lead to tumor progression and metastasis. Furthermore it interacts with proteins like beta-catenin involved in both Wnt signaling and oncogenesis. Alterations in R Cadherin expression also relate to certain retinal degenerative diseases emphasizing its importance in maintaining structured tissue integrity and signaling.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.

See full target information Cadherin-4

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

eLife 14: PubMed40938188

2025

Gene regulatory mechanisms guiding bifurcation of inhibitory and excitatory neuron lineages in the mouse anterior brainstem.

Applications

Unspecified application

Species

Unspecified reactive species

Sami Kilpinen,Lassi Virtanen,Silvana Bodington Celma,Amos Bonsdorff,Heidi Heliölä,Kaia Achim,Juha Partanen

Journal of Parkinson's disease 13:1303-1311 PubMed38143373

2023

Understanding the Role of CDH4 in Multiple System Atrophy Brain.

Applications

Unspecified application

Species

Unspecified reactive species

Finula I Isik,Jared S Katzeff,YuHong Fu,Woojin Scott Kim

Oncology letters 17:4819-4826 PubMed31186688

2019

MicroRNA-9 enhances chemotherapy sensitivity of glioma to TMZ by suppressing TOPO II via the NF-κB signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Qingla Li,Yingnan Chang,Luyan Mu,Yuwen Song

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-R Cadherin antibody [EPR4836]

Western blot - Anti-R Cadherin antibody [EPR4836] (AB109242)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

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