Rabbit Polyclonal RAB18 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Ras-related protein Rab-18.
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 1% BSA
Lyophilized
Polyclonal
WB | IHC-P | |
---|---|---|
Human | Tested | Tested |
Rat | Predicted | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/1000 - 1/2000 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Rat | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/100 - 1/500 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Rat | Dilution info - | Notes - |
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The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:24891604, PubMed:30970241). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:24891604, PubMed:30970241). Required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts (PubMed:30970241). Also required for maintaining endoplasmic reticulum structure (PubMed:24891604). Plays a role in apical endocytosis/recycling (By similarity). Plays a key role in eye and brain development and neurodegeneration (PubMed:21473985).
Ras-related protein Rab-18, RAB18
Rabbit Polyclonal RAB18 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Ras-related protein Rab-18.
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 1% BSA
Lyophilized
Polyclonal
Affinity purification Immunogen
Reconstitute in 200 µL of water
ab119900 is purified by a protein affinity column.
Blue Ice
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
Rab18 also known as RAB18A or RAB18 is a member of the Rab GTPase family a group of proteins involved in intracellular vesicle trafficking. Rab18 is approximately 23 kDa in mass. Researchers find Rab18 expressed widely in various tissues including the brain liver and adipose tissue. As a small GTPase Rab18 switches between an inactive GDP-bound state and an active GTP-bound state regulating membrane trafficking and fusion processes.
The functions of Rab18 extend beyond simple vesicular transport. Rab18 interacts with lipid droplets and the endoplasmic reticulum influencing lipid metabolism and storage. It is sometimes present in a complex with proteins like TBC1D20 which acts as a GAP (GTPase-activating protein) that further regulates Rab18’s activity. Through these interactions Rab18 influences lipid homeostasis and endoplasmic reticulum organization adding a layer of control to cellular lipid balance.
Rab18 participates in the regulation of lipid droplet growth and maturation linking it to lipid metabolism pathways. Its activity plays a role in the tethering of lipid droplets to the endoplasmic reticulum relating it functionally to proteins such as Seipin. Additionally Rab18 is involved in intracellular transport pathways where it cooperates with other Rab proteins like Rab3 and Rab10 to facilitate membrane trafficking and organelle dynamics.
Rab18 associations are evident in conditions like Warburg Micro syndrome and intellectual disability. Warburg Micro syndrome characterized by eye and brain abnormalities emerges from mutations affecting Rab18 or its interacting partners like RAB3GAP. Similarly Rab18’s involvement in lipid metabolism connects it with metabolic disorders where lipid storage and synthesis disruptions play a role. This links the functionality of Rab18 in cellular processes to broader impacts on human health.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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All lanes: Western blot - Anti-Rab18 antibody (ab119900) at 1/1000 dilution
All lanes: Human fetal testis lysate
Predicted band size: 23 kDa, 24 kDa
Observed band size: 23 kDa
ab119900 at 1/100 dilution staining Rab18 in Formalin-fixed, Paraffin-embedded Human prostate carcinoma tissue by Immunohistochemistry.
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