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Rabbit Polyclonal RAB20 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human Ras-related protein Rab-20 aa 1-200.

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Images

Western blot - Anti-Rab20 antibody (AB105043), expandable thumbnail
  • Immunocytochemistry/ Immunofluorescence - Anti-Rab20 antibody (AB105043), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine)

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human Ras-related protein Rab-20 aa 1-200. The exact immunogen used to generate this antibody is proprietary information. Database link Q9NX57

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBICC/IF
Human
Tested
Tested

Tested
Tested

Species

Human

Dilution info

1/500.00000 - 1/3000.00000

Notes

-

Tested
Tested

Species

Human

Dilution info

1/100.00000 - 1/500.00000

Notes

-

Associated Products

Select an associated product type

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Target data

Function

Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes.

Alternative names

Recommended products

Rabbit Polyclonal RAB20 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human Ras-related protein Rab-20 aa 1-200.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human Ras-related protein Rab-20 aa 1-200. The exact immunogen used to generate this antibody is proprietary information. Database link Q9NX57
Purification technique

Affinity purification Immunogen

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Rab20 also known as Ras-related protein Rab-20 is a small GTPase belonging to the Rab protein family. Rab20 has a molecular mass of approximately 25 kDa. It is expressed across a variety of tissues with notable presence in the kidney placenta and heart. Rab20's mechanical role involves the regulation of vesicular trafficking operating as a molecular switch by cycling between an active GTP-bound state and an inactive GDP-bound state.

Biological function summary

Rab20 regulates intracellular membrane transport processes. It is involved in endocytic and exocytic transport pathways by controlling vesicle formation movement and fusion. Rab20 participates in the recycling of endosomes contributing to the homeostasis of cellular components. Rab20 is also involved in a complex with other Rab proteins modulating their specific functions in vesicle trafficking.

Pathways

Rab20 plays a role in the endocytic pathway specifically in the recycling endosome pathway where it acts alongside proteins such as Rab11. Rab20 supports the retrieval and recycling of receptors from endosomes back to the plasma membrane. Related to this function Rab20 associates with the exocytic pathway ensuring proper transport of cargo proteins from the Golgi apparatus to the cell surface.

Associated diseases and disorders

Rab20 has associations with cancer progression and hepatocellular carcinoma. It exhibits altered expression levels in tumors suggesting a role in cell proliferation and metastasis. Furthermore Rab20 may influence autophagic processes in cells impacting conditions such as neurodegenerative disorders. In cancer pathology Rab20 interacts with other proteins such as Ras regulating cell growth and survival pathways.

Product promise

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2 product images

  • Western blot - Anti-Rab20 antibody (ab105043), expandable thumbnail

    Western blot - Anti-Rab20 antibody (ab105043)

    12% SDS PAGE

    All lanes: Western blot - Anti-Rab20 antibody (ab105043) at 1/1000 dilution

    All lanes: HeLa whole cell lysate at 30 µg

    Predicted band size: 26 kDa

  • Immunocytochemistry/ Immunofluorescence - Anti-Rab20 antibody (ab105043), expandable thumbnail

    Immunocytochemistry/ Immunofluorescence - Anti-Rab20 antibody (ab105043)

    ab105043, at a 1/200 dilution, staining Rab20 in methanol-fixed HeLa cells. Right image is costained with Hoechst 33342.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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