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AB105043

Anti-Rab20 antibody

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(1 Publication)

Rabbit Polyclonal RAB20 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RAB20 aa 1-200.

View Alternative Names

Ras-related protein Rab-20, RAB20

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-Rab20 antibody (AB105043)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Rab20 antibody (AB105043)

ab105043, at a 1/200 dilution, staining Rab20 in methanol-fixed HeLa cells. Right image is costained with Hoechst 33342.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human RAB20 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

Q9NX57

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Rab20 also known as Ras-related protein Rab-20 is a small GTPase belonging to the Rab protein family. Rab20 has a molecular mass of approximately 25 kDa. It is expressed across a variety of tissues with notable presence in the kidney placenta and heart. Rab20's mechanical role involves the regulation of vesicular trafficking operating as a molecular switch by cycling between an active GTP-bound state and an inactive GDP-bound state.
Biological function summary

Rab20 regulates intracellular membrane transport processes. It is involved in endocytic and exocytic transport pathways by controlling vesicle formation movement and fusion. Rab20 participates in the recycling of endosomes contributing to the homeostasis of cellular components. Rab20 is also involved in a complex with other Rab proteins modulating their specific functions in vesicle trafficking.

Pathways

Rab20 plays a role in the endocytic pathway specifically in the recycling endosome pathway where it acts alongside proteins such as Rab11. Rab20 supports the retrieval and recycling of receptors from endosomes back to the plasma membrane. Related to this function Rab20 associates with the exocytic pathway ensuring proper transport of cargo proteins from the Golgi apparatus to the cell surface.

Rab20 has associations with cancer progression and hepatocellular carcinoma. It exhibits altered expression levels in tumors suggesting a role in cell proliferation and metastasis. Furthermore Rab20 may influence autophagic processes in cells impacting conditions such as neurodegenerative disorders. In cancer pathology Rab20 interacts with other proteins such as Ras regulating cell growth and survival pathways.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB20 plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes.
See full target information RAB20
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Redox biology 79:103472 PubMed39752998

2025

Molecular hydrogen reduces dermatitis-induced itch, diabetic itch and cholestatic itch by inhibiting spinal oxidative stress and synaptic plasticity via SIRT1-β-catenin pathway in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Linlin Zhang,Fangshi Zhao,Yize Li,Zhenhua Song,Lingyue Hu,Yuanjie Li,Rui Zhang,Yonghao Yu,Guolin Wang,Chunyan Wang
View all publications
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Product promise

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