Rabbit Polyclonal RAB20 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human Ras-related protein Rab-20 aa 1-200.
IgG
Rabbit
pH: 7
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
WB | ICC/IF | |
---|---|---|
Human | Tested | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/100.00000 - 1/500.00000 | Notes - |
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Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes.
Ras-related protein Rab-20, RAB20
Rabbit Polyclonal RAB20 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human Ras-related protein Rab-20 aa 1-200.
IgG
Rabbit
pH: 7
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
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This supplementary information is collated from multiple sources and compiled automatically.
Rab20 also known as Ras-related protein Rab-20 is a small GTPase belonging to the Rab protein family. Rab20 has a molecular mass of approximately 25 kDa. It is expressed across a variety of tissues with notable presence in the kidney placenta and heart. Rab20's mechanical role involves the regulation of vesicular trafficking operating as a molecular switch by cycling between an active GTP-bound state and an inactive GDP-bound state.
Rab20 regulates intracellular membrane transport processes. It is involved in endocytic and exocytic transport pathways by controlling vesicle formation movement and fusion. Rab20 participates in the recycling of endosomes contributing to the homeostasis of cellular components. Rab20 is also involved in a complex with other Rab proteins modulating their specific functions in vesicle trafficking.
Rab20 plays a role in the endocytic pathway specifically in the recycling endosome pathway where it acts alongside proteins such as Rab11. Rab20 supports the retrieval and recycling of receptors from endosomes back to the plasma membrane. Related to this function Rab20 associates with the exocytic pathway ensuring proper transport of cargo proteins from the Golgi apparatus to the cell surface.
Rab20 has associations with cancer progression and hepatocellular carcinoma. It exhibits altered expression levels in tumors suggesting a role in cell proliferation and metastasis. Furthermore Rab20 may influence autophagic processes in cells impacting conditions such as neurodegenerative disorders. In cancer pathology Rab20 interacts with other proteins such as Ras regulating cell growth and survival pathways.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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12% SDS PAGE
All lanes: Western blot - Anti-Rab20 antibody (ab105043) at 1/1000 dilution
All lanes: HeLa whole cell lysate at 30 µg
Predicted band size: 26 kDa
ab105043, at a 1/200 dilution, staining Rab20 in methanol-fixed HeLa cells. Right image is costained with Hoechst 33342.
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