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AB197209

Anti-Rab20 antibody

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(2 Publications)

Rabbit Polyclonal RAB20 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RAB20 aa 1 to C-terminus.

View Alternative Names

Ras-related protein Rab-20, RAB20

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Rab20 antibody (AB197209)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Rab20 antibody (AB197209)

Immunohistochemical analysis of formalin-fixed paraffin-embedded human prostate cancer tissue labeling Rab20 with ab197209 at a 1/100 dilution.

Western blot - Anti-Rab20 antibody (AB197209)
  • WB

Supplier Data

Western blot - Anti-Rab20 antibody (AB197209)

All lanes:

Western blot - Anti-Rab20 antibody (ab197209) at 1/500 dilution

Lane 1:

HeLa cell lysate

Lane 2:

MCF7 cell lysate

Predicted band size: 26 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human RAB20 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9NX57

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
reconstitute with water at 200µL
Purification technique
Affinity purification Immunogen
Storage buffer
Preservative: 0.02% Sodium azide Constituents: BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Rab20 also known as Ras-related protein Rab-20 is a small GTPase belonging to the Rab protein family. Rab20 has a molecular mass of approximately 25 kDa. It is expressed across a variety of tissues with notable presence in the kidney placenta and heart. Rab20's mechanical role involves the regulation of vesicular trafficking operating as a molecular switch by cycling between an active GTP-bound state and an inactive GDP-bound state.
Biological function summary

Rab20 regulates intracellular membrane transport processes. It is involved in endocytic and exocytic transport pathways by controlling vesicle formation movement and fusion. Rab20 participates in the recycling of endosomes contributing to the homeostasis of cellular components. Rab20 is also involved in a complex with other Rab proteins modulating their specific functions in vesicle trafficking.

Pathways

Rab20 plays a role in the endocytic pathway specifically in the recycling endosome pathway where it acts alongside proteins such as Rab11. Rab20 supports the retrieval and recycling of receptors from endosomes back to the plasma membrane. Related to this function Rab20 associates with the exocytic pathway ensuring proper transport of cargo proteins from the Golgi apparatus to the cell surface.

Rab20 has associations with cancer progression and hepatocellular carcinoma. It exhibits altered expression levels in tumors suggesting a role in cell proliferation and metastasis. Furthermore Rab20 may influence autophagic processes in cells impacting conditions such as neurodegenerative disorders. In cancer pathology Rab20 interacts with other proteins such as Ras regulating cell growth and survival pathways.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes.
See full target information RAB20
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 25: PubMed39201692

2024

STAT3 Increases CVB3 Replication and Acute Pancreatitis and Myocarditis Pathology via Impeding Nuclear Translocation of STAT1 and Interferon-Stimulated Gene Expression.

Applications

Unspecified application

Species

Unspecified reactive species

Tianming Liang,Zhipeng Zhang,Zhenxin Bai,Le Xu,Wei Xu

Cancers 14: PubMed35267417

2022

RAB20 Promotes Proliferation via G2/M Phase through the Chk1/cdc25c/cdc2-cyclinB1 Pathway in Penile Squamous Cell Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Xingliang Tan,Gangjun Yuan,Yanjun Wang,Yuantao Zou,Sihao Luo,Hui Han,Zike Qin,Zhuowei Liu,Fangjian Zhou,Yanling Liu,Kai Yao
View all publications
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