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AB192420

Anti-RAB23 antibody

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(1 Publication)

Rabbit Polyclonal RAB23 antibody. Suitable for WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human RAB23.

View Alternative Names

HSPC137, RAB23, Ras-related protein Rab-23

1 Images
Western blot - Anti-RAB23 antibody (AB192420)
  • WB

Supplier Data

Western blot - Anti-RAB23 antibody (AB192420)

All lanes:

Western blot - Anti-RAB23 antibody (ab192420)

Lane 1:

MCF7 whole cell lysate

Lane 2:

HEK293T whole cell lysate

Lane 3:

NIH 3T3 whole cell lysate

Predicted band size: 27 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human RAB23. The exact immunogen used to generate this antibody is proprietary information.

Q9ULC3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/5", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/5", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Purity is > 95% (by SDS-PAGE).
Storage buffer
pH: 7.2 Preservative: 0.05% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RAB23 also known as Ras-related protein Rab-23 is a small GTPase of the RAB family. It has a molecular weight of approximately 25 kDa. This protein is expressed in various tissues with significant expression in the brain skin and kidney. RAB23 acts as a molecular switch by cycling between inactive GDP-bound and active GTP-bound states. It regulates intracellular vesicle trafficking influencing the movement and fusion of vesicles within the cell.
Biological function summary

RAB23 plays an important role in modulating various cellular processes such as intracellular transport and signal transduction. It interacts with effector proteins through its active GTP-bound form which allows it to facilitate certain cellular functions. RAB23 is known to associate with specific protein complexes contributing to pathways that affect cellular movement and organization reflecting its importance in cellular dynamics.

Pathways

RAB23 is a part of the Hedgehog signaling pathway involved in embryonic development and cell differentiation. Within this pathway RAB23 regulates the activity of proteins like GLI transcription factors to control gene expression important for developmental processes. Additionally RAB23 interacts with other GTPases linking to the actin cytoskeleton remodeling pathway which impacts cellular structure and polarity.

RAB23 has been linked to certain congenital conditions such as Carpenter syndrome which involves malformations in the skull and limbs. Mutations in the RAB23 gene can disrupt normal Hedgehog signaling leading to developmental defects. Furthermore the protein's association with GLI transcription factors connects it to various developmental disorders marked by alterations in early patterning and organ formation. Such links underline the significance of RAB23 in developmental biology and its potential as a therapeutic target.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes.
See full target information RAB23
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Oncology letters 15:5155-5160 PubMed29552151

2018

Rab23 promotes the cisplatin resistance of ovarian cancer via the Shh-Gli-ABCG2 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Wenjie Zhang,Feng Yu,Yu Wang,Yu Zhang,Lingxin Meng,Yuhua Chi
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