AB198202

Anti-RAB26 antibody

Name: Anti-RAB26 antibody (ab198202) | Abcam
Brand: Abcam Limited
SKU: AB198202
Price: 535 USD
Availability: InStock

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(5 Publications)

Rabbit Polyclonal RAB26 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human RAB26.

View Alternative Names

Ras-related protein Rab-26, RAB26

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RAB26 antibody (AB198202)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RAB26 antibody (AB198202)

Immunohistochemical analysis of paraffin-embedded Human ovarian cancer tissue using ab198202 at dilution 1/60.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RAB26 antibody (AB198202)

Immunohistochemical analysis of paraffin-embedded Human gasrtic cancer tissue using ab198202 at dilution 1/60.

Unknown

Western blot - Anti-RAB26 antibody (AB198202)

Gel : 12%SDS-PAGE

All lanes:

Western blot - Anti-RAB26 antibody (ab198202) at 1/200 dilution

Lane 1:

MCF7 cells at 40 µg

Lane 2:

A375 cells at 40 µg

Secondary

All lanes:

Goat anti rabbit IgG at 1/8000 dilution

Predicted band size: 28 kDa

false

Exposure time: 5s

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human RAB26. The exact immunogen used to generate this antibody is proprietary information.

Q9ULW5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/25 - 1/100", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Product details

Members of the RAB protein family, including RAB26, are important regulators of vesicular fusion and trafficking. The RAB family of small G proteins regulates intercellular vesicle trafficking, including exocytosis, endocytosis, and recycling. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RAB26 also known as Ras-related protein Rab-26 is a member of the Ras oncogene family. This protein has a mass of about 25 kilodaltons (kDa). Functionally RAB26 engages in intracellular membrane trafficking. Expression of RAB26 is prominent in the brain particularly in neuronal and glandular tissues where it plays an important role in vesicle transport and secretion processes.

Biological function summary

RAB26 facilitates the movement and regulation of secretory vesicles. It is part of the small GTPase complex a group of proteins involved in vesicle formation transport and fusion. RAB26 regulates the targeting and fusion of vesicles to specific sites within the cell contributing to the precise delivery of cargo like neurotransmitters and enzymes.

Pathways

RAB26 is critical in the exocytotic pathways that govern vesicular traffic and secretion. It closely interacts with proteins such as synaptotagmin and VAMP2 which are essential in synaptic vesicle fusion. Additionally RAB26 is involved in pathways that manage stress responses in cells interacting with proteins like RAB3 further modulating vesicle dynamics during cellular stress.

RAB26 has associations with neurological disorders including Parkinson's disease and some forms of epilepsy. These conditions often involve dysfunctional vesicular trafficking pathways. In Parkinson's disease RAB26 interacts with proteins like alpha-synuclein which accumulate and lead to neurodegeneration. In epilepsy irregularities in vesicle release processes implicate RAB26 and similar small GTPases. Understanding RAB26's role in these disorders helps to elucidate potential therapeutic targets.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland.

See full target information RAB26

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

The FEBS journal 290:4023-4039 PubMed37060270

2023

Rab26 promotes macrophage phagocytosis through regulation of MFN2 trafficking to mitochondria.

Applications

Unspecified application

Species

Unspecified reactive species

Di Wu,Yao Wang,Junxian Hu,Yuhang Xu,Daohui Gong,Pengfei Wu,Junkang Dong,Binfeng He,Hang Qian,Guansong Wang

Bioengineered 13:8064-8075 PubMed35291909

2022

RAB26 contributes to the progression of non-small cell lung cancer after being transcriptionally activated by SMAD3.

Applications

Unspecified application

Species

Unspecified reactive species

Haixia Ren,Bo Yang,Mingjiang Li,Chunling Lu,Xiaoping Li

Frontiers in immunology 12:768435 PubMed34925338

2021

Extracellular CIRP-Impaired Rab26 Restrains EPOR-Mediated Macrophage Polarization in Acute Lung Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Wen Zhang,Yao Wang,Chuanwei Li,Yu Xu,Xia Wang,Di Wu,Zhan Gao,Hang Qian,Zaichun You,Zhiren Zhang,Binfeng He,Guansong Wang

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 8:e2004852 PubMed34180133

2021

RBFOX2/GOLIM4 Splicing Axis Activates Vesicular Transport Pathway to Promote Nasopharyngeal Carcinogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Chun-Ling Luo,Xiao-Chen Xu,Chu-Jun Liu,Shuai He,Jie-Rong Chen,Yan-Chun Feng,Shu-Qiang Liu,Wan Peng,Ya-Qing Zhou,Yu-Xiang Liu,Pan-Pan Wei,Bo Li,Hai-Qiang Mai,Xiao-Jun Xia,Jin-Xin Bei

Cell death & disease 10:667 PubMed31511502

2019

SNRPB promotes the tumorigenic potential of NSCLC in part by regulating RAB26.

Applications

Unspecified application

Species

Unspecified reactive species

Nianli Liu,Zhiyuan Wu,Aoxing Chen,Yuqi Wang,Dafei Cai,Junian Zheng,Yong Liu,Longzhen Zhang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-RAB26 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RAB26 antibody (AB198202)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RAB26 antibody (AB198202)

Western blot - Anti-RAB26 antibody (AB198202)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (5)

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