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AB187151

Anti-RAB26 antibody [EPR15975(B)] - C-terminal

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(4 Publications )

Rabbit Recombinant Monoclonal RAB26 antibody. C-terminal. Suitable for WB and reacts with Human samples. Cited in 4 publications.
2 Images
Western blot - Anti-RAB26 antibody [EPR15975(B)] - C-terminal (AB187151)
  • WB

Supplier Data

Western blot - Anti-RAB26 antibody [EPR15975(B)] - C-terminal (AB187151)

All lanes:

Western blot - Anti-RAB26 antibody [EPR15975(B)] - C-terminal (ab187151) at 1/1000 dilution

All lanes:

U87-MG cell lysate at 20 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Predicted band size: 28 kDa

false

Western blot - Anti-RAB26 antibody [EPR15975(B)] - C-terminal (AB187151)
  • WB

Unknown

Western blot - Anti-RAB26 antibody [EPR15975(B)] - C-terminal (AB187151)

Blocking and diluting buffer 5% NFDM/TBST

All lanes:

Western blot - Anti-RAB26 antibody [EPR15975(B)] - C-terminal (ab187151) at 1/10000 dilution

All lanes:

Human hippocampus lysate at 20 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Predicted band size: 28 kDa,33 kDa

false

  • Carrier free

    Anti-RAB26 antibody [EPR15975(B)] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR15975(B)

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Conditional Ambient
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RAB26 also known as Ras-related protein Rab-26 is a member of the Ras oncogene family. This protein has a mass of about 25 kilodaltons (kDa). Functionally RAB26 engages in intracellular membrane trafficking. Expression of RAB26 is prominent in the brain particularly in neuronal and glandular tissues where it plays an important role in vesicle transport and secretion processes.
Biological function summary

RAB26 facilitates the movement and regulation of secretory vesicles. It is part of the small GTPase complex a group of proteins involved in vesicle formation transport and fusion. RAB26 regulates the targeting and fusion of vesicles to specific sites within the cell contributing to the precise delivery of cargo like neurotransmitters and enzymes.

Pathways

RAB26 is critical in the exocytotic pathways that govern vesicular traffic and secretion. It closely interacts with proteins such as synaptotagmin and VAMP2 which are essential in synaptic vesicle fusion. Additionally RAB26 is involved in pathways that manage stress responses in cells interacting with proteins like RAB3 further modulating vesicle dynamics during cellular stress.

RAB26 has associations with neurological disorders including Parkinson's disease and some forms of epilepsy. These conditions often involve dysfunctional vesicular trafficking pathways. In Parkinson's disease RAB26 interacts with proteins like alpha-synuclein which accumulate and lead to neurodegeneration. In epilepsy irregularities in vesicle release processes implicate RAB26 and similar small GTPases. Understanding RAB26's role in these disorders helps to elucidate potential therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB26 mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane (PubMed : 23105096). Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach (PubMed : 20038531). Plays a role in the secretion of amylase from acinar granules in the parotid gland (By similarity).
See full target information RAB26

Alternative Names

Ras-related protein Rab-26, RAB26
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Publications (4)

Recent publications for all applications. Explore the full listand refine your search

Scientific reports 15:24802 PubMed40634549

2025

Small molecule compound ZYZ-384 targets SMYD3 to alleviate aging.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Liu,Dan Han,Li Jin,Xuena Xie,Huibo Li,Qian Ding,Yizhun Zhu

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 8:e2004852 PubMed34180133

2021

RBFOX2/GOLIM4 Splicing Axis Activates Vesicular Transport Pathway to Promote Nasopharyngeal Carcinogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Chun-Ling Luo,Xiao-Chen Xu,Chu-Jun Liu,Shuai He,Jie-Rong Chen,Yan-Chun Feng,Shu-Qiang Liu,Wan Peng,Ya-Qing Zhou,Yu-Xiang Liu,Pan-Pan Wei,Bo Li,Hai-Qiang Mai,Xiao-Jun Xia,Jin-Xin Bei

Autophagy :1-17 PubMed32116095

2020

effector protein CvpF subverts RAB26-dependent autophagy to promote vacuole biogenesis and virulence.

Applications

Unspecified application

Species

Unspecified reactive species

Fernande Ayenoue Siadous,Franck Cantet,Erin Van Schaik,Mélanie Burette,Julie Allombert,Anissa Lakhani,Boris Bonaventure,Caroline Goujon,James Samuel,Matteo Bonazzi,Eric Martinez

Autophagy 14:1677-1692 PubMed29965781

2018

RAB26-dependent autophagy protects adherens junctional integrity in acute lung injury.

Applications

Unspecified application

Species

Unspecified reactive species

Weijie Dong,Binfeng He,Hang Qian,Qian Liu,Dong Wang,Jin Li,Zhenghua Wei,Zi Wang,Zhi Xu,Guangyu Wu,Guisheng Qian,Guansong Wang
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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