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AB192393

Anti-RAB30 antibody

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(1 Publication)

Rabbit Polyclonal RAB30 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Ras-related protein Rab-30 aa 100-200.

View Alternative Names

Ras-related protein Rab-30, RAB30

1 Images
Western blot - Anti-RAB30 antibody (AB192393)
  • WB

Supplier Data

Western blot - Anti-RAB30 antibody (AB192393)

All lanes:

Western blot - Anti-RAB30 antibody (ab192393)

Lane 1:

HeLa whole cell lysate

Lane 2:

Mouse liver tissue lysate

Lane 3:

Rat liver tissue lysate

Predicted band size: 23 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human Ras-related protein Rab-30 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.

Q15771

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Primary Antibodies

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab192393 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage buffer
Preservative: 0.1% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RAB30 is a small GTPase that belongs to the RAB family which functions in intracellular membrane trafficking. Sometimes referred to as Ras-related protein Rab-30 it weighs approximately 23 kDa. This protein facilitates the movement of vesicles between different cellular compartments. RAB30 is widely expressed in many tissues including the brain liver and lungs suggesting a diverse role within the body in managing vesicular transport and communication between organelles.
Biological function summary

The regulation of vesicle trafficking involves RAB30 and other Rab GTPases. They act as molecular switches cycling between inactive GDP-bound and active GTP-bound states. Though RAB30 does not appear as part of a larger complex it works closely with effector molecules that help determine cargo movement and specificity. The active RAB30 can recruit specific effectors to vesicles guiding them in the cellular sorting processes and aiding in maintaining cellular homeostasis.

Pathways

RAB30 is primarily involved in the endocytic and exocytic pathways. It ensures proper vesicle formation budding and fusion events that are essential for cellular communication. Related proteins like RAB1 and RAB8 also play pivotal roles in these pathways orchestrating a coordinated effort during vesicular trafficking. RAB30 adapts its functionality in response to different cellular needs integrating signals to manage the flow of proteins and lipids across cellular compartments.

Alterations or dysregulation in RAB30 expression or function have connections to cancer and neurodegenerative diseases. In cancer its role in regulating trafficking can affect cell signaling and growth potentially relating to proteins like RAB7 which is involved in endosomal trafficking and degradation pathways. In neurodegenerative diseases improper RAB30 activity may disrupt neuronal communication linking it to dysfunctional pathways connected to proteins like LRRK2 an important regulator in cellular transport processes associated with Parkinson's disease.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins.
See full target information Ras-related protein Rab-30
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of cachexia, sarcopenia and muscle 16:e70002 PubMed40745399

2025

Exogenous Nucleotides Supplementation Attenuates Age-Related Sarcopenia.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Wu,Rui Liu,Na Zhu,Xiujuan Wang,Chan Wei,Xiaoyang An,Meihong Xu,Yong Li
View all publications
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Product promise

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