Anti-RAB39 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

RAB39 also referred to as RAB39B is a small GTPase part of the Ras superfamily with a molecular mass of about 24 kDa. It is generally expressed in the brain especially in neurons and is also seen in the liver and testis. The protein acts as a molecular switch cycling between an active GTP-bound state and an inactive GDP-bound state and helps in intracellular vesicle trafficking.

Biological function summary

RAB39B regulates important functions related to the formation and movement of endosomes. It is involved in directing the transport of intracellular vesicles ensuring the accurate delivery of molecules within the cell. RAB39B operates as part of a larger protein complex contributing to the sorting and maturation of endosomes processes vital for cellular communication and cargo distribution.

Pathways

RAB39B plays a significant role in endocytic and autophagic pathways linking its activity to cellular homeostasis. It coordinates with other proteins such as LRRK2 and VPS35 to maintain the dynamic nature of membrane trafficking. These pathways are essential in cellular maintenance allowing the recycling of cellular components and the removal of damaged organelles.

Associated diseases and disorders

RAB39B mutations have connections to neurological conditions like Parkinson’s disease and X-linked intellectual disabilities. RAB39B mutations disrupt the normal functioning of pathways and lead to neuronal damage. In Parkinson's disease its interaction with proteins like LRRK2 becomes evident where dysregulation in these pathways can contribute to the pathogenesis of neurodegenerative disorders.