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AB235518

Anti-RAB3B antibody

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(1 Publication)

Rabbit Polyclonal RAB3B antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Ras-related protein Rab-3B.

View Alternative Names

Ras-related protein Rab-3B, RAB3B

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RAB3B antibody (AB235518)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RAB3B antibody (AB235518)

Paraffin-embedded human colon cancer tissue stained for RAB3B using ab235518 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human Ras-related protein Rab-3B.

P20337

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Alternative Products

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Primary Antibodies

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Primary Antibodies

AB193360

Anti-RAB7B antibody [EPR15727]

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Hamster": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RAB3B is a small GTPase belonging to the RAB protein family known for its role in regulating vesicle trafficking. It is also referred to as Ras-related protein Rab-3B. The molecular mass of RAB3B is approximately 25 kDa. This protein is primarily expressed in the brain although it shows presence in other tissues as well. RAB3B functions by cycling between an active GTP-bound state and an inactive GDP-bound state facilitating the control of intracellular vesicle movement and positioning.
Biological function summary

RAB3B participates in synaptic vesicle exocytosis an important process in neurotransmitter release at synapses. It is part of the exocytotic machinery complex that coordinates vesicle docking and fusion with target membranes. This protein plays a significant role in ensuring effective neurotransmission which is important for neuronal communication. Given its role in synaptic function RAB3B contributes to the regulation of synaptic plasticity and memory formation.

Pathways

RAB3B is actively involved in the regulation of the synaptic vesicle cycle and exocytosis pathways. These pathways are important in neurotransmitter release and recycling in neurons. In the synaptic vesicle cycle RAB3B interacts with proteins like RAB3A and Munc-18 which play roles in vesicle docking and fusion. These interactions ensure the coordination and timing of neurotransmitter release which is essential for accurate neuronal signaling.

Mutations or dysregulation of RAB3B have been implicated in neurological conditions such as epilepsy and Alzheimer's disease. In epilepsy the disruption of normal synaptic vesicle trafficking can lead to abnormal neuronal excitability. Similarly in Alzheimer's disease altered vesicle transport associated with RAB3B may contribute to synaptic dysfunction and cognitive decline. RAB3B's interaction with other synaptic proteins becomes a critical factor in understanding its involvement in these disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed : 35871249). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed : 35871249).
See full target information Ras-related protein Rab-3B
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cancer medicine 12:5035-5054 PubMed36205357

2022

Systemic analysis of the DNA replication regulator origin recognition complex in lung adenocarcinomas identifies prognostic and expression significance.

Applications

Unspecified application

Species

Unspecified reactive species

Min Tang,Juan Chen,Tian Zeng,Dong-Mei Ye,Yu-Kun Li,Juan Zou,Yu-Ping Zhang
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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