Anti-RAB3B antibody [EPR12987] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

RAB3B is a small GTPase belonging to the RAB protein family known for its role in regulating vesicle trafficking. It is also referred to as Ras-related protein Rab-3B. The molecular mass of RAB3B is approximately 25 kDa. This protein is primarily expressed in the brain although it shows presence in other tissues as well. RAB3B functions by cycling between an active GTP-bound state and an inactive GDP-bound state facilitating the control of intracellular vesicle movement and positioning.

Biological function summary

RAB3B participates in synaptic vesicle exocytosis an important process in neurotransmitter release at synapses. It is part of the exocytotic machinery complex that coordinates vesicle docking and fusion with target membranes. This protein plays a significant role in ensuring effective neurotransmission which is important for neuronal communication. Given its role in synaptic function RAB3B contributes to the regulation of synaptic plasticity and memory formation.

Pathways

RAB3B is actively involved in the regulation of the synaptic vesicle cycle and exocytosis pathways. These pathways are important in neurotransmitter release and recycling in neurons. In the synaptic vesicle cycle RAB3B interacts with proteins like RAB3A and Munc-18 which play roles in vesicle docking and fusion. These interactions ensure the coordination and timing of neurotransmitter release which is essential for accurate neuronal signaling.

Associated diseases and disorders

Mutations or dysregulation of RAB3B have been implicated in neurological conditions such as epilepsy and Alzheimer's disease. In epilepsy the disruption of normal synaptic vesicle trafficking can lead to abnormal neuronal excitability. Similarly in Alzheimer's disease altered vesicle transport associated with RAB3B may contribute to synaptic dysfunction and cognitive decline. RAB3B's interaction with other synaptic proteins becomes a critical factor in understanding its involvement in these disorders.