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AB201305

Anti-RAB41 antibody

4

(5 Reviews)

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(1 Publication)

Rabbit Polyclonal RAB41 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human RAB41 aa 100-200.

View Alternative Names

Ras-related protein Rab-41, RAB41

1 Images
Western blot - Anti-RAB41 antibody (AB201305)
  • WB

Supplier Data

Western blot - Anti-RAB41 antibody (AB201305)

All lanes:

Western blot - Anti-RAB41 antibody (ab201305)

Lane 1:

HEK293T whole cell lysate

Lane 2:

Raw264.7 whole cell lysate

Lane 3:

H9C2 whole cell lysate

Predicted band size: 25 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human RAB41 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.

Q5JT25

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Purity is > 95% (by SDS-PAGE).
Storage buffer
pH: 7.3 Preservative: 0.05% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RAB41 also known as Ras-related protein Rab-41 is a member of the Rab family of GTPases and plays a critical role in the regulation of vesicular trafficking. This protein has a mass of approximately 25 kDa. RAB41 exerts its mechanical functions by cycling between an active GTP-bound form and an inactive GDP-bound form. It is expressed in various tissues with notable expression in brain liver and lung tissues. Its localization suggests diverse roles in different cellular compartments particularly in the early stages of the Golgi apparatus.
Biological function summary

The Ras-related protein Rab family member 41 engages in intracellular vesicle transport processes and the maintenance of Golgi integrity. It interacts with other proteins as part of a complex that facilitates the proper sorting and delivery of proteins and lipids throughout the cell. RAB41 involvement is essential in the formation and trafficking of Golgi-derived vesicles impacting cellular functions like protein secretion membrane protein localization and recycling pathways.

Pathways

Vesicle-mediated transport and the secretory pathway are major systems involving RAB41. In these pathways RAB41 associates with other proteins such as Coatomer Protein Complex I (COPI) and is instrumental in the retrograde vesicle transport from the Golgi to the endoplasmic reticulum. This involvement highlights its significance in maintaining proper cellular homeostasis and efficient cargo delivery and recycling within the cell.

Abnormal RAB41 function has been implicated in cancer and neurodegenerative diseases. Altered expression or mutation may contribute to the progression of cancer by disrupting normal vesicle transport and cellular communication. Additionally RAB41 dysfunction relates to neurodegenerative disorders through its connection with proteins like Tau which are important in maintaining neuronal health. Understanding these relationships can aid in developing therapeutic targets for related diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed : 23936529). RAB41 is required for normal Golgi ribbon organization and ER-to-Golgi trafficking (PubMed : 23936529).
See full target information RAB41
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cardiovascular research 119:2213-2229 PubMed37395010

2023

Tissue-specific differences in the assembly of mitochondrial Complex I are revealed by a novel ENU mutation in ECSIT.

Applications

Unspecified application

Species

Unspecified reactive species

Thomas Nicol,Sara Falcone,Andrew Blease,Pratik Vikhe,Gabriele Civiletto,Saleh Salman Omairi,Carlo Viscomi,Ketan Patel,Paul K Potter
View all publications
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Product promise

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