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AB179948

Anti-RAB4B antibody - N-terminal

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(1 Review)

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(1 Publication)

Rabbit Polyclonal RAB4B antibody. N-terminal. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human RAB4B aa 1-100 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

RAB4, PP1596, RAB4B, Ras-related protein Rab-4B

2 Images
Western blot - Anti-RAB4B antibody - N-terminal (AB179948)
  • WB

Supplier Data

Western blot - Anti-RAB4B antibody - N-terminal (AB179948)

All lanes:

Western blot - Anti-RAB4B antibody - N-terminal (ab179948) at 1/100 dilution

All lanes:

CEM cell lysate at 35 µg

Predicted band size: 24 kDa

false

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RAB4B antibody - N-terminal (AB179948)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RAB4B antibody - N-terminal (AB179948)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human kidney tissue labeling RAB4B with ab179948 at 5 μg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human RAB4B aa 1-100 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P61018

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100 - 1/500", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Zebrafish": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RAB4B also known as Ras-related protein Rab-4B is a small GTPase with a molecular mass of approximately 24 kDa. This protein plays a mechanical role in controlling intracellular vesicle trafficking particularly involved in endosomal recycling. It facilitates the movement of membrane-bound vesicles within cells impacting various cellular processes. RAB4B is mostly expressed in tissues such as brain testis and kidney suggesting specialized roles in these regions.
Biological function summary

RAB4B mediates the sorting and recycling of receptors from the early endosome back to the plasma membrane or to other cellular destinations. As a member of the Rab protein family it often associates with protein complexes that include its effectors and other small GTPases. This network facilitates its role in maintaining cellular homeostasis and contributing to the traffic of cargo proteins to their intended cellular compartments.

Pathways

RAB4B is a significant participant in pathways such as the endocytosis pathway and receptor recycling. In these pathways it closely interacts with other proteins like RAB11A and RAB5 where they coordinate functions in sorting and recycling of endocytic vesicles. RAB4B assists in transitioning cargo from early endosomes to recycling endosomes or returning them to the cell surface therefore impacting cellular signal transduction and nutrient uptake.

Researchers have seen potential links between RAB4B dysregulation and neurological disorders as well as certain cancers. Aberrations in RAB4B expression or function might affect endosome dynamics contributing to disease progression. In certain cancers for example the altered trafficking of membrane receptors can drive tumor growth and metastasis possibly interacting with proteins like EGFR which is important for cell proliferation and survival.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (Probable). Mediates endosomal tethering and fusion through the interaction with RUFY1 and RAB14 (PubMed : 20534812). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity).
See full target information RAB4B
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Asia-Pacific journal of clinical oncology 17:253-263 PubMed33078907

2020

LINC01133 promotes the progression of cervical cancer via regulating miR-30a-5p/FOXD1.

Applications

Unspecified application

Species

Unspecified reactive species

Dan Zhang,Yuyang Zhang,Xiuyun Sun
View all publications
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