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AB206110

Anti-RAB6B antibody

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(1 Publication)

Rabbit Polyclonal RAB6B antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Ras-related protein Rab-6B aa 1-200.

View Alternative Names

Ras-related protein Rab-6B, RAB6B

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RAB6B antibody (AB206110)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RAB6B antibody (AB206110)

Immunohistochemical analysis of formalin/-fixed, paraffin-embedded section of Human fetal tonsil tissue labeling RAB6B with ab206110 at a 1/100 dilution.

Western blot - Anti-RAB6B antibody (AB206110)
  • WB

Supplier Data

Western blot - Anti-RAB6B antibody (AB206110)

All lanes:

Western blot - Anti-RAB6B antibody (ab206110) at 1/500 dilution

All lanes:

Human RAB6B recombinant protein

Predicted band size: 23 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human Ras-related protein Rab-6B aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

Q9NRW1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Product details

We have not tested this product against RAB6A. ab206110 may cross react with RAB6A.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RAB6B also known as ras-related protein Rab-6B is a small GTPase with a molecular weight of approximately 24 kDa. It plays a mechanical role in intracellular trafficking processes specifically in the regulation of vesicular transport and Golgi apparatus function. RAB6B is widely expressed in human tissues with heightened levels observed in brain tissue particularly in cerebral cortex neurons and the central nervous system. This makes it important for understanding neurological processes and maintaining cellular homeostasis in such tissues.
Biological function summary

RAB6B acts in coordination with components of the vesicle transport machinery. It is not part of a large protein complex but interacts with several regulatory proteins to ensure accurate vesicle movement and docking within cells. This protein mainly influences retrograde transport from the Golgi back to the endoplasmic reticulum. This activity supports the recycling of proteins and lipids aiding in the proper maintenance of the Golgi structure and overall cellular function.

Pathways

RAB6B modulates significant pathways related to membrane trafficking. It has pronounced involvement in the retrograde vesicle transport pathway impacting the transport of cargos in neurons. RAB6B's interaction with other RAB proteins especially with members such as RAB3 and RAB8 influences synaptic vesicle exocytosis and endosomal sorting. This highlights its role in neurotransmitter release and synaptic plasticity which are important for neuronal communication.

Abnormalities in RAB6B expression and function associate with neurological disorders particularly Alzheimer's disease and Autism Spectrum Disorder. In Alzheimer's RAB6B's interaction with amyloid precursor protein (APP) influences amyloid-beta peptide generation an important event in disease pathology. In autism altered RAB6B activities potentially affect synaptic vesicle trafficking leading to impaired neural connectivity and function. Understanding these connections can provide deeper insights into the mechanisms behind these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (By similarity). Recruits VPS13B to the Golgi membrane (PubMed : 25492866). Regulates the compacted morphology of the Golgi (PubMed : 26209634). Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (PubMed : 17707369). Plays a role in neuron projection development (PubMed : 25492866).
See full target information Ras-related protein Rab-6B
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of extracellular vesicles 7:1490144 PubMed30034643

2018

Molecular subtypes and differentiation programmes of glioma stem cells as determinants of extracellular vesicle profiles and endothelial cell-stimulating activities.

Applications

Unspecified application

Species

Unspecified reactive species

C Spinelli,L Montermini,B Meehan,A R Brisson,S Tan,D Choi,I Nakano,J Rak
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Product promise

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