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AB124356

Anti-RAB8B antibody

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(1 Publication)

Rabbit Polyclonal RAB8B antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Ras-related protein Rab-8B.

View Alternative Names

Ras-related protein Rab-8B, RAB8B

1 Images
Western blot - Anti-RAB8B antibody (AB124356)
  • WB

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Western blot - Anti-RAB8B antibody (AB124356)

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Western blot - Anti-RAB8B antibody (ab124356) at 1/1000 dilution

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Human Fetal Thymus lysate

Predicted band size: 24 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human Ras-related protein Rab-8B.

Q92930

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
Reconstitute in 200 µL of water
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RAB8B also known as RAB8 or RAB8B isoform is a member of the RAS oncogene family and is a small GTPase enzyme with a molecular mass of approximately 23 kDa. This protein plays an important role in vesicular trafficking and membrane transport processes. It is widely expressed in various tissues including the brain liver and kidney. RAB8B modulates cytoskeletal dynamics and is involved in the regulation of polarized membrane transport enabling cargo trafficking along microtubules and actin filaments.
Biological function summary

The small GTPase protein RAB8B assists in numerous cellular processes by influencing membrane trafficking. It facilitates the exocytic pathway and controls cargo delivery from the trans-Golgi network to the cell surface. RAB8B collaborates with effector proteins to form complexes that ensure correct vesicle fusion and membrane targeting. This protein is integral in maintaining cellular homeostasis and influencing processes like ciliogenesis essential for cell growth and signaling.

Pathways

Cellular processes involve RAB8B operating in the exocytic and endocytic pathways. Within these pathways RAB8B interacts closely with proteins like RAB11 and RAB5 which are important regulators of membrane transport. RAB8B ensures proper trafficking by regulating vesicle sorting and recycling which affects overall cellular functions. These interactions help coordinate receptor recycling and signal transduction pathways imperative for cellular communication and response.

RAB8B is connected to conditions such as microvillus inclusion disease and Bardet-Biedl syndrome. RAB8B influences these disorders through its role in membrane trafficking and ciliogenesis. Dysfunction in RAB8B and its association with proteins like BBS1 in Bardet-Biedl syndrome can disrupt cilia function leading to multisystemic effects. This highlights the significance of RAB8B as a potential target for therapeutic intervention in these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity). May participate in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route (PubMed : 32344433).
See full target information Ras-related protein Rab-8B
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 18:508-519 PubMed28076793

2017

Chloroquine-Inducible Par-4 Secretion Is Essential for Tumor Cell Apoptosis and Inhibition of Metastasis.

Applications

Unspecified application

Species

Unspecified reactive species

Ravshan Burikhanov,Nikhil Hebbar,Sunil K Noothi,Nidhi Shukla,James Sledziona,Nathália Araujo,Meghana Kudrimoti,Qing Jun Wang,David S Watt,Danny R Welch,Jodi Maranchie,Akihiro Harada,Vivek M Rangnekar
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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