Anti-Rabenosyn 5 antibody - C-terminal

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Rabenosyn-5 also known as RBSN or ZFYVE20 is a protein involved in endosomal trafficking. It has a mass of approximately 83 kDa. This protein functions mechanically by binding to early endosomes through its FYVE domain interacting with the small GTPase Rab5. Rabenosyn-5 is expressed in various tissues with higher levels in cells involved in active endocytosis.

Biological function summary

Rabenosyn-5 plays a role in endosomal membrane fusion in part by acting as a tethering effector for early endosomes. It is part of a larger protein complex that includes EEA1 which modulates membrane tethering and fusion events essential for endocytosis and receptor recycling processes. The protein helps facilitate sorting and trafficking of internalized molecules within cells influencing signal transduction and cellular responses to environmental changes.

Pathways

Rabenosyn-5 participates in the early endosome pathway which is important for sorting endocytosed material and regulating membrane trafficking. This protein interacts with Rab5 and is involved in the conversion of early endosomes to late endosomes. It also indirectly influences the endocytic recycling pathway where its activity is linked to the regulation of various receptors on the cell surface including those in receptor-mediated signaling cascades.

Associated diseases and disorders

Alterations in Rabenosyn-5 function impact conditions such as neurodegenerative diseases and certain cancers. In Alzheimer's disease disrupted endosomal trafficking may contribute to disease progression in which Rabenosyn-5 along with proteins like LRP1 can influence amyloid beta clearance. In cancer dysregulated endocytosis can affect cell growth signaling pathways and its interaction with Rab5a may alter the trafficking efficiency of growth factor receptors playing a critical role in tumor cell proliferation.