Rabbit Polyclonal RABEP1 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human RABEP1 aa 800 to C-terminus.
View Alternative Names
RAB5EP, RABPT5, RABPT5A, RABEP1, Rab GTPase-binding effector protein 1, Rabaptin-4, Rabaptin-5, Rabaptin-5alpha, Renal carcinoma antigen NY-REN-17
- IP
Supplier Data
Immunoprecipitation - Anti-RABEP1 antibody (AB176578)
Detection of RABEP1 in Immunoprecipitates of HeLa whole cell lysates (1 mg for IP, 20% of IP loaded) using ab176578 at 3 μg/mg lysate for IP (Lane 1). For WB detection ab176578 antibody which recognizes an upstream epitope was used at 0.4 μg/ml. Lane 2 represents control IgG IP.
Detection : Chemiluminescence with exposure time of 3 seconds.
All lanes:
Immunoprecipitation - Anti-RABEP1 antibody (ab176578)
Predicted band size: 99 kDa
true
Exposure time: 3s
- WB
Supplier Data
Western blot - Anti-RABEP1 antibody (AB176578)
All lanes:
Western blot - Anti-RABEP1 antibody (ab176578) at 0.04 µg/mL
Lane 1:
HeLa whole cell lysates at 50 µg
Lane 2:
HeLa whole cell lysates at 15 µg
Lane 3:
HeLa whole cell lysates at 5 µg
Lane 4:
293T whole cell lysates at 50 µg
Lane 5:
NIH3T3 whole cell lysates at 50 µg
Predicted band size: 99 kDa
true
Exposure time: 30s
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Reactivity data
Properties and storage information
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Purification technique
Purification notes
Storage buffer
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
RABEP1 functions as a central component in early endosome fusion and trafficking processes. It often forms part of a complex with the Rab5 protein facilitating the tethering and docking of vesicles within the intracellular environment. Through its interactions it plays roles in processes such as endocytosis and recycling of membrane receptors. The RABEP1's activities ensure proper sorting and transport of cargo molecules contributing to cellular homeostasis.
Pathways
RABEP1 contributes significantly to both the endocytic and recycling pathways. It associates closely with the Rab family of GTPases particularly Rab5 during the early stages of endosomal transport. This protein helps in transitioning cargo through the endosomes an important part of the Rab5-related endocytic pathway. Also RABEP1 works collaboratively with the EEA1 protein assisting in the regulation of early endosome membrane fusion and cargo sorting.
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Target data
Publications (2)
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Cell death & disease 15:752 PubMed39419978
2024
Applications
Unspecified application
Species
Unspecified reactive species
CNS neuroscience & therapeutics 30:e14743 PubMed38780008
2024
Applications
Unspecified application
Species
Unspecified reactive species
Product promise
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