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AB128726

Anti-Rabies Virus antibody [Rab-50]

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(1 Publication)

Mouse Monoclonal Rabies Virus antibody. Suitable for ELISA, WB, ICC/IF and reacts with Rabies virus samples. Cited in 1 publication. Immunogen corresponding to Virus preparation containing Rabies Virus protein.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

Rab-50

Isotype

IgG2b

Carrier free

No

Reacts with

Rabies virus

Applications

ELISA, WB, ICC/IF

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

ab128726 shows conformation dependent specificity for the viral envelope glycoprotein. Not known to react with any other organism.

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Complementary Products

Primary Antibodies

AB3863

FITC Anti-VSV-G tag antibody

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Proteins & Peptides

AB225663

Recombinant Rabies Virus Glycoprotein (His tag)

SDS-PAGE - Recombinant Rabies Virus Glycoprotein (His tag) (AB225663)

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Primary Antibodies

AB214337

Anti-Flavivirus NS1 antibody [D/2/D6/B7]

Immunocytochemistry/ Immunofluorescence - Anti-Flavivirus NS1 antibody [D/2/D6/B7] (AB214337)

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rabies virus": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }
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Product details

Should this product contain a precipitate we recommend microcentrifugation before use. Storage in frost-free freezers is not recommended. Spleen cells from immunised Balb/c female mice were fused with cells of the NSO myeloma cell line
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Properties and storage information

Form
Liquid
Purification technique
Precipitation Ammonium Sulphate
Storage buffer
Preservative: 0.09% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Rabies Virus also known scientifically as Lyssavirus is a neurotropic virus with a negative-sense single-stranded RNA genome. Its genome has a mass of approximately 12000 nucleotides. The virus mainly expresses itself in the central nervous system of mammals including humans. The structure comprises a helical ribonucleoprotein core surrounded by a viral envelope. This form of viral organization facilitates its movement through neuronal tissues and across synapses.
Biological function summary

The Rabies Virus is responsible for the transmission of rabies a fatal encephalitis. The virus operates by invading the nervous system effectively avoiding the host's immune response through rapid neural transmission. It forms complexes with host cellular machinery to hijack cellular processes for its replication and dissemination. The virus reaches high concentrations in the brain and salivary glands leading to its transmission through animal bites.

Pathways

Several neural entry and propagation routes are implicated in Rabies Virus infection. The molecular pathways involve interactions with neuronal cell membrane receptors and require other proteins such as nicotinic acetylcholine receptor for effective binding. The viral proteins including glycoprotein play critical roles in facilitating these interactions which modulate the transmission pathways across the nervous system.

Rabies Virus is directly related to the disease rabies a neurodegenerative condition resulting in fatal encephalitis if untreated. Understanding its pathway helps in developing vaccines and therapeutic strategies like anti-rabies immunoglobulins. The virus's interaction with proteins such as the nicotinic acetylcholine receptor highlights potential therapeutic targets to limit neural invasion and control the disorder's progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Rabies Virus
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Biomacromolecules 25:6485-6502 PubMed39214607

2024

Harnessing the Biomimetic Effect of Macromolecular Crowding in the Cell-Derived Model of Clubfoot Fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Martina Doubková,Jarmila Knitlová,David Vondrášek,Adam Eckhardt,Tomáš Novotný,Martin Ošt'ádal,Elena Filová,Lucie Bačáková
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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