Anti-Rad51 antibody [RAD51/2702]
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Mouse Monoclonal Rad51 antibody. Suitable for Flow Cyt, Protein Array, IHC-P and reacts with Human, Recombinant full length protein - Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human RAD51 aa 1-150.
View Alternative Names
RAD51A, RECA, RAD51, DNA repair protein RAD51 homolog 1, HsRAD51, hRAD51, RAD51 homolog A
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Rad51 antibody [RAD51/2702] (AB269677)
Formalin-fixed, paraffin-embedded human colon carcinoma tissue stained for Rad51 using ab269677 at 2 μg/ml in immunohistochemical analysis.
- Flow Cyt
Supplier Data
Flow Cytometry - Anti-Rad51 antibody [RAD51/2702] (AB269677)
Flow cytometric analysis of K562 (human chronic myelogenous leukemia cell line from bone marrow) cells labeling Rad51 using ab269677 ar 2 μg/ml (Blue) compared to an isotype control (Red). The secondary antibody is a Goat anti-Mouse IgG-CF488 conjugate.
- Protein Array
Supplier Data
Protein Array - Anti-Rad51 antibody [RAD51/2702] (AB269677)
Analysis of Protein Array containing more than 19,000 full-length human proteins using ab269677.
Z- and S- Score : The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Reactivity data
Properties and storage information
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Purification technique
Purification notes
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Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Processes involving RAD51 are essential for genomic stability and cellular response to DNA damage. RAD51 often functions as part of a repair complex along with other proteins such as BRCA2 and RPA. This complex binds and stabilizes single-stranded DNA during search and strand invasion which is vital for successful recombination repair. Such repair mechanisms are important for preventing chromosomal aberrations and maintaining genetic integrity.
Pathways
RAD51's activity fits into the broader context of DNA damage repair pathways notably the homologous recombination (HR) pathway. This pathway is important for repairing double-strand breaks utilizing other proteins such as ATM and ATR to signal repair processes. Furthermore RAD51 interacts with various members of the BRCA protein family combining efforts to ensure proper DNA damage response and repair.
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Target data
Product promise
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