AB95202

Anti-RAET1E antibody [79/6/13/16]

Name: Anti-RAET1E antibody [79/6/13/16] (ab95202) | Abcam
Brand: Abcam Limited
SKU: AB95202
Price: 535 USD
Availability: InStock

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(5 Publications)

Mouse Monoclonal RAET1E antibody. Suitable for IP, Flow Cyt, ELISA, WB, FuncS (Neut/Block), ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RAET1E aa 1-250.

View Alternative Names

LETAL, N2DL4, ULBP4, UNQ1867/PRO4303, RAET1E, Retinoic acid early transcript 1E, Lymphocyte effector toxicity activation ligand, NKG2D ligand 4, RAE-1-like transcript 4, UL16-binding protein 4, N2DL-4, NKG2DL4

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

79/6/13/16

Isotype

IgG2a

Carrier free

Reacts with

Human

Applications

ICC/IF, Flow Cyt, ELISA, IP, FuncS (Neut/Block), WB

applications

Immunogen

Recombinant Fragment Protein within Human RAET1E aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

Q8TD07

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "FuncSNeutBlock" : {"fullname" : "Functional Studies (Neut/Block)", "shortname":"FuncS (Neut/Block)"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<a href='/en-us/products/primary-antibodies/mouse-igg2c-kappa-monoclonal-18c8bc7ad10-isotype-control-ab170191'>ab170191</a> - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "FuncSNeutBlock-species-checked": "guaranteed", "FuncSNeutBlock-species-dilution-info": "", "FuncSNeutBlock-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A/G

Storage buffer

Preservative: 0.02% Sodium azide Constituents: 99.98% PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RAET1E also known as UL16-binding protein 4 (ULBP4) is a member of the MHC class I-related molecules. It has a molecular mass of approximately 31 kDa. RAET1E is part of the family of proteins that acts as a ligand for the NKG2D receptor found on the surface of natural killer (NK) cells. In terms of expression RAET1E is present on the surface of various cell types especially in stressed transformed or virus-infected cells where it signals cellular distress to immune cells.

Biological function summary

RAET1E plays a role in immune surveillance. It is involved in the activation of NK cells when it binds to the NKG2D receptor. This interaction is part of the body's defense mechanism against transformed or infected cells. RAET1E operates in isolation rather than as part of a larger protein complex which allows it to independently initiate the immune response when detecting harmful cells.

Pathways

RAET1E functions within the innate immune response pathway. It works closely with the NKG2D signaling pathway which is important for the activation of cytotoxic activities in immune cells. RAET1E through its binding to NKG2D facilitates the destruction of malignant cells. This connection places RAET1E alongside other similar NKG2D ligands such as MIC and other ULBP family proteins which contribute to the activation of NK and T cells.

RAET1E is linked to various cancer types and infectious diseases. Its expression on the surface of tumor cells can signal NK cells to target and destroy these potentially harmful cells. In certain cancers the loss or reduction of RAET1E expression may allow tumor cells to escape immune detection. In viral infections the upregulation of RAET1E on infected cells assists in the clearance of viruses by NK cells. Both in cancer and viral infections proteins like RAET1E and NKG2D play an important part in the immune system's defensive strategies.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.

See full target information RAET1E

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 10:e2202519 PubMed36683155

2023

Metabolic Reprogramming of NK Cells by Black Phosphorus Quantum Dots Potentiates Cancer Immunotherapy.

Applications

Unspecified application

Species

Unspecified reactive species

Lizhen He,Jianfu Zhao,Hongjun Li,Bin Xie,Ligeng Xu,Guanning Huang,Ting Liu,Zhen Gu,Tianfeng Chen

Helicobacter 26:e12812 PubMed33928707

2021

Heat-killed Helicobacter pylori upregulates NKG2D ligands expression on gastric adenocarcinoma cells via Toll-like receptor 4.

Applications

Unspecified application

Species

Unspecified reactive species

Carolina Hernández,Karen Toledo-Stuardo,Paulina García-González,Macarena Garrido-Tapia,Karina Kramm,José Alejandro Rodríguez-Siza,Marcela Hermoso,Carolina H Ribeiro,María Carmen Molina

Oncoimmunology 9:1746148 PubMed32363114

2020

Targeting ubiquitin protein ligase E3 component N-recognin 5 in cancer cells induces a CD8+ T cell mediated immune response.

Applications

Unspecified application

Species

Unspecified reactive species

Mei Song,Chao Wang,Huan Wang,Tuo Zhang,Jiuqi Li,Robert Benezra,Lotfi Chouchane,Yin-Hao Sun,Xin-Gang Cui,Xiaojing Ma

Oncoimmunology 6:e1358839 PubMed29147621

2017

In-depth immunophenotyping of patients with glioblastoma multiforme: Impact of steroid treatment.

Applications

Unspecified application

Species

Unspecified reactive species

Guranda Chitadze,Charlotte Flüh,Elgar Susanne Quabius,Sandra Freitag-Wolf,Christian Peters,Marcus Lettau,Jaydeep Bhat,Daniela Wesch,Hans-Heinrich Oberg,Stefanie Luecke,Ottmar Janssen,Michael Synowitz,Janka Held-Feindt,Dieter Kabelitz

International journal of cancer 135:1390-8 PubMed24615495

2014

Therapeutic potential of highly cytotoxic natural killer cells for gastric cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Kousaku Mimura,Takahiro Kamiya,Kensuke Shiraishi,Ley-Fang Kua,Asim Shabbir,Jimmy So,Wei-Peng Yong,Yoshiyuki Suzuki,Yuya Yoshimoto,Takashi Nakano,Hideki Fujii,Dario Campana,Koji Kono

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-RAET1E antibody [79/6/13/16]

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (5)

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