Anti-Ramp4-2 antibody [EPR14338]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Ramp4-2 also known as Ribosome-associated membrane protein 4-2 plays a role in the endoplasmic reticulum (ER) where it assists in protein synthesis and translocation. It is a small protein with a mass of approximately 8 kDa. Ramp4-2 is widely expressed in many tissues indicating its important function in cellular activities. This protein helps facilitate the movement of nascent polypeptides across the ER membrane ensuring proper folding and function of synthesized proteins.

Biological function summary

Ramp4-2 facilitates the assembly and stabilization of proteins as part of a ribosome-nascent chain complex. It ensures efficient translocation of polypeptides into the ER lumen where they fold and mature. By being part of this complex Ramp4-2 aids in maintaining the efficient functioning of protein translocation machinery thereby supporting overall protein homeostasis in cells. Its involvement in such cellular processes highlights its essential role in maintaining proper cellular function and protein balance.

Pathways

The Ramp4-2 protein engages with several other elements in the secretory pathway particularly the translocation pathway at the ER. It interacts closely with signal recognition particle (SRP) to guide ribosome-mRNA complexes to the ER. It also has connections to the complex involving Sec61 a translocon channel which facilitates polypeptide translocation into the ER. This participation indicates its importance in the ER stress response pathway acting alongside other components to ensure proper folding and processing of secreted and membrane-bound proteins.

Associated diseases and disorders

Ramp4-2 has links to certain pathologies where protein misfolding or ER stress plays a role. Dysregulation or mutations in proteins associated with Ramp4-2 may contribute to neurodegenerative diseases such as Alzheimer's disease given the protein's integral role in protein folding and homeostasis. Likewise it may intersect with disorders related to metabolic dysregulation as it participates in pathways important for maintaining cellular proteostasis. Ramp4-2's interactions with proteins involved in these diseases highlight its potential relevance in therapeutic research and intervention strategies.