Mouse Monoclonal RANK antibody. Suitable for IHC-P, IP and reacts with Human, Mouse samples. Cited in 28 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TNFRSF11A.
Images
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RANK antibody [64C1385] (AB13918), expandable thumbnail](https://content.abcam.com/products/images/rank-antibody-64c1385-ab13918--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img137880.png/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RANK antibody [64C1385] (AB13918)"){kind=icon}
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RANK antibody [64C1385] (AB13918), expandable thumbnail](https://content.abcam.com/products/images/rank-antibody-64c1385-ab13918--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img68700.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RANK antibody [64C1385] (AB13918)"){kind=icon}
Publications
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- Journal of clinical medicine 12:2023Jaw Bone Invasion of Oral Squamous Cell Carcinoma Is Associated with Osteoclast Count and Expression of Its Regulating Proteins in Patients and Organoids.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWillem W B de Kort,Wisse E Haakma,Robert J J van Es,Debby Gawlitta,Else Driehuis,Merel Gansevoort,Stefan M WillemsPubMed 37762975
- Cells 12:2023RANKL Inhibition Reduces Cardiac Hypertrophy in Mice and Possibly in Children with Duchenne Muscular Dystrophy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLaetitia Marcadet,Emma Sara Juracic,Nasrin Khan,Zineb Bouredji,Hideo Yagita,Leanne M Ward,A Russell Tupling,Anteneh Argaw,Jérôme FrenettePubMed 37296659
- eLife 12:2023RANKTLR2 myeloid subpopulation converts autoimmune to joint destruction in rheumatoid arthritis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWeixin Zhang,Kathleen Noller,Janet Crane,Mei Wan,Xiaojun Wu,Patrick Cahan,Xu CaoPubMed 37204303
- iScience 26:1064702023An inducible explant model of osteoclast-osteoprogenitor coordination in exacerbated osteoclastogenesis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJarred M Whitlock,Luis F de Castro,Michael T Collins,Leonid V Chernomordik,Alison M BoycePubMed 37091244
- Advances in clinical and experimental medicine : official organ Wroclaw Medical University 32:245-2592022Prognostic relevance of clinicopathological factors in sporadic and syndromic odontogenic keratocysts: A comparative study.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKonrad Kisielowski,Bogna Drozdzowska,Mariusz Szuta,Tomasz KaczmarzykPubMed 36226690
- Nature communications 13:28992022Anoctamin 1 controls bone resorption by coupling Cl channel activation with RANKL-RANK signaling transduction.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWeijia Sun,Shuai Guo,Yuheng Li,JianWei Li,Caizhi Liu,Yafei Chen,Xuzhao Wang,Yingjun Tan,Hua Tian,Cheng Wang,Ruikai Du,Guohui Zhong,Sai Shi,Biao Ma,Chang Qu,Jingxuan Fu,Xiaoyan Jin,Dingsheng Zhao,Yong Zhan,Shukuan Ling,Hailong An,Yingxian LiPubMed 35610255
- Nature communications 13:25392022SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWei Qiao,Hui En Lau,Huizhi Xie,Vincent Kwok-Man Poon,Chris Chung-Sing Chan,Hin Chu,Shuofeng Yuan,Terrence Tsz-Tai Yuen,Kenn Ka-Heng Chik,Jessica Oi-Ling Tsang,Chris Chun-Yiu Chan,Jian-Piao Cai,Cuiting Luo,Kwok-Yung Yuen,Kenneth Man-Chee Cheung,Jasper Fuk-Woo Chan,Kelvin Wai-Kwok YeungPubMed 35534483
- Heliyon 8:e086912022Total body proton and heavy-ion irradiation causes cellular senescence and promotes pro-osteoclastogenic activity in mouse bone marrow.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKamendra Kumar,Kamal Datta,Albert J Fornace,Shubhankar SumanPubMed 35028468
- Brazilian dental journal 32:16-252021RANK, RANKL, and OPG in Dentigerous Cyst, Odontogenic Keratocyst, and Ameloblastoma: A Meta-Analysis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesIgor Felipe Pereira Lima,Felipe Rodrigues de Matos,Ítalo de Macedo Bernardino,Ingrede Tatiane Serafim Santana,Walbert de Andrade Vieira,Cauane Blumenberg,Walter Luiz Siqueira,Luiz Renato ParanhosPubMed 33913997
- Cell death & disease 12:3362021RANK promotes colorectal cancer migration and invasion by activating the Ca-calcineurin/NFATC1-ACP5 axis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesQian Liang,Yun Wang,Yingsi Lu,Qingqing Zhu,Wenlin Xie,Nannan Tang,Lifen Huang,Tailai An,Di Zhang,Anqi Yan,Shaoyu Liu,Liping Ye,Chengming ZhuPubMed 33795653
Key facts
- Isotype
- IgG1
- Host species
- Mouse
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- Recombinant Fragment Protein within Human TNFRSF11A. The exact immunogen used to generate this antibody is proprietary information. Database link Q9Y6Q6
Abcam Recommends
Reactivity data
Select an application| IHC-P | IP | |
|---|---|---|
| Human | Tested | Expected |
| Mouse | Expected | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 5 µg/mL | Notes Perform heat-mediated antigen retrieval before commencing with IHC staining protocol. |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
IP
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1.00000-2.00000 µg/mL | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
Associated Products
Select an associated product type
3 products for Alternative Product
Target data
Function
Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis (PubMed:9878548). Its interaction with EEIG1 promotes osteoclastogenesis via facilitating the transcription of NFATC1 and activation of PLCG2 (By similarity). Involved in the regulation of interactions between T-cells and dendritic cells (By similarity).
Alternative names
CD265, RANK, TNFRSF11A, Tumor necrosis factor receptor superfamily member 11A, Osteoclast differentiation factor receptor, Receptor activator of NF-KB, ODFR
Recommended products
Mouse Monoclonal RANK antibody. Suitable for IHC-P, IP and reacts with Human, Mouse samples. Cited in 28 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TNFRSF11A.
Key facts
- Isotype
- IgG1
- Host species
- Mouse
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- Recombinant Fragment Protein within Human TNFRSF11A. The exact immunogen used to generate this antibody is proprietary information. Database link Q9Y6Q6
- Clone number
- 64C1385
- Purification technique
- Affinity purification Protein G
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
3 product images
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RANK antibody [64C1385] (ab13918), expandable thumbnail](https://content.abcam.com/products/images/rank-antibody-64c1385-ab13918--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img137880.png "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RANK antibody [64C1385] (ab13918)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RANK antibody [64C1385] (ab13918)
Formaldehyde-fixed, paraffin-embedded human skin tissue stained for RANK using ab13918 at 1/50 dilution in immunohistochemical analysis.
![Immunoprecipitation - Anti-RANK antibody [64C1385] (ab13918), expandable thumbnail](https://content.abcam.com/products/images/rank-antibody-64c1385-ab13918--immunoprecipitation-img66659.gif "Immunoprecipitation - Anti-RANK antibody [64C1385] (ab13918)")
Immunoprecipitation - Anti-RANK antibody [64C1385] (ab13918)
Detection of RANK in RAW cells. Lane 1: mouse cell line. Lane 2 & 3: IP/Western blot analysis of RANK. RANK protein from RAW cell lysate was immunoprecipitated either with control antibody (lane 2) or ab13918 (lane 3), and detected with ab13918.
All lanes: Immunoprecipitation - Anti-RANK antibody [64C1385] (ab13918)
Predicted band size: 66 kDa
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RANK antibody [64C1385] (ab13918), expandable thumbnail](https://content.abcam.com/products/images/rank-antibody-64c1385-ab13918--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img68700.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RANK antibody [64C1385] (ab13918)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RANK antibody [64C1385] (ab13918)
IHC image of ab13918 staining in human t cell lymphoma formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab13918, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.
Downloads
Product protocols
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