Rabbit Polyclonal RANKL antibody. Suitable for IHC-P and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TNFSF11 aa 150-300.
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- Advances in clinical and experimental medicine : official organ Wroclaw Medical University 32:245-2592022Prognostic relevance of clinicopathological factors in sporadic and syndromic odontogenic keratocysts: A comparative study.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKonrad Kisielowski,Bogna Drozdzowska,Mariusz Szuta,Tomasz KaczmarzykPubMed 36226690
- Frontiers in physiology 12:7671362021Mechanosensitive Piezo1 in Periodontal Ligament Cells Promotes Alveolar Bone Remodeling During Orthodontic Tooth Movement.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYukun Jiang,Yuzhe Guan,Yuanchen Lan,Shuo Chen,Tiancheng Li,Shujuan Zou,Zhiai Hu,Qingsong YePubMed 34880779
- Advances in clinical and experimental medicine : official organ Wroclaw Medical University 30:301-3072021Immunoexpression of RANK, RANKL and OPG in sporadic odontogenic keratocysts and their potential association with recurrence.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKonrad Kisielowski,Bogna Drozdzowska,Rafał Koszowski,Magdalena Rynkiewicz,Mariusz Szuta,Mansur Rahnama,Karolina Babiuch,Michał Tyrakowski,Anna Bednarczyk,Tomasz KaczmarzykPubMed 33768738
- Bioactive materials 6:3074-30842021Lithium chloride promotes osteogenesis and suppresses apoptosis during orthodontic tooth movement in osteoporotic model via regulating autophagy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLi Huang,Xing Yin,Jun Chen,Ruojing Liu,Xiaoyue Xiao,Zhiai Hu,Yan He,Shujuan ZouPubMed 33778189
- Stem cell research & therapy 11:1712020Bone marrow mesenchymal stem cells improve bone erosion in collagen-induced arthritis by inhibiting osteoclasia-related factors and differentiating into chondrocytes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJinfang Gao et. al.PubMed 32381074
- Bosnian journal of basic medical sciences 17:295-3012017Berberine alleviates oxidative stress in rats with osteoporosis through receptor activator of NF-kB/receptor activator of NF-kB ligand/osteoprotegerin (RANK/RANKL/OPG) pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiao-Feng He,Long Zhang,Chun-Hua Zhang,Con-Ran Zhao,Heng Li,Ling-Fei Zhang,Guo-Feng Tian,Ming-Feng Guo,Zheng Dai,Fu-Ge SuiPubMed 29055350
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA- Form
- Lyophilized
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human TNFSF11 aa 150-300. The exact immunogen used to generate this antibody is proprietary information. Database link O14788
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100.00000 - 1/500.00000 | Notes - |
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Target data
Function
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (PubMed:22664871). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (By similarity).
Alternative names
CD254, OPGL, RANKL, TRANCE, TNFSF11, Tumor necrosis factor ligand superfamily member 11, Osteoclast differentiation factor, Osteoprotegerin ligand, Receptor activator of nuclear factor kappa-B ligand, TNF-related activation-induced cytokine, ODF
Recommended products
Rabbit Polyclonal RANKL antibody. Suitable for IHC-P and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TNFSF11 aa 150-300.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA- Form
- Lyophilized
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human TNFSF11 aa 150-300. The exact immunogen used to generate this antibody is proprietary information. Database link O14788
- Purification technique
- Affinity purification Immunogen
- Reconstitution
- Reconstitute with 200ul distilled sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RANKL antibody (ab169966)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human fetal colon tissue labeling RANKL with ab169966 at 1/100 dilution.
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