AB239607

Anti-RANKL antibody [C1]

Name: Anti-RANKL antibody [C1] (ab239607) | Abcam
Brand: Abcam Limited
SKU: AB239607
Price: 425 USD
Availability: InStock

(1 Review)

(21 Publications)

Mouse Monoclonal RANKL antibody. Suitable for WB and reacts with Rat, Recombinant full length protein - Rat samples. Cited in 21 publications. Immunogen corresponding to Recombinant Fragment Protein within Rat Tnfsf11 aa 100-250.

View Alternative Names

CD254, Opgl, Rankl, Trance, Tnfsf11, Tumor necrosis factor ligand superfamily member 11, Osteoclast differentiation factor, Osteoprotegerin ligand, Receptor activator of nuclear factor kappa-B ligand, TNF-related activation-induced cytokine, ODF, OPGL, RANKL, TRANCE

2 Images

Supplier Data

Western blot - Anti-RANKL antibody [C1] (AB239607)

All lanes:

Western blot - Anti-RANKL antibody [C1] (ab239607) at 5 µg/mL

All lanes:

Rat thymus tissue lysate

Secondary

All lanes:

HRP-Goat Anti-Mouse IgG

Predicted band size: 35 kDa

false

Supplier Data

Western blot - Anti-RANKL antibody [C1] (AB239607)

All lanes:

Western blot - Anti-RANKL antibody [C1] (ab239607) at 5 µg/mL

All lanes:

Recombinant rat RANKL protein

Predicted band size: 35 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

Isotype

IgG2a

Light chain type

kappa

Carrier free

Reacts with

Rat

Applications

applications

Immunogen

Recombinant Fragment Protein within Rat Tnfsf11 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.

Q9ESE2

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Recombinant full length protein - Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A/G

Purification notes

Purified from TCS.

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

style

left-column

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation.

See full target information Tnfsf11

style

left-column

Publications (21)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:20701 PubMed40596392

2025

Black tea rich in polygonatum sibiricum polysaccharides inhibits osteoporosis in ovariectomized mice through immune regulation and gut microbiota suppression.

Applications

Unspecified application

Species

Unspecified reactive species

Shiyu Gao,Yikang Yu,Jialu Shu,Biqian Yang,Baiqiao Zhang,Jinhao Xu,Zhenwei Wang

BMC oral health 25:78 PubMed39819670

2025

Investigation of the preventive effect of methylsulfonylmethane on alveolar bone loss and oxidative stress in a rat model of periodontitis.

Applications

Unspecified application

Species

Unspecified reactive species

Melek Beder,Hatice Yemenoglu,Semih Alperen Bostan,Oğuz Kose,Sibel Mataracı Karakas,Tolga Mercantepe,Adnan Yılmaz,Levent Tumkaya

Signal transduction and targeted therapy 8:280 PubMed37500654

2023

Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms.

Applications

Unspecified application

Species

Unspecified reactive species

Na Jia,Yunzhen Gao,Min Li,Yi Liang,Yuwen Li,Yunzhu Lin,Shiqi Huang,Qing Lin,Xun Sun,Qin He,Yuqin Yao,Ben Zhang,Zhirong Zhang,Ling Zhang

Journal of orthopaedic surgery and research 18:234 PubMed36949499

2023

Daytime administration of melatonin has better protective effects on bone loss in ovariectomized rats.

Applications

Unspecified application

Species

Unspecified reactive species

Tian-Lin Li,He-Dong Liu,Mao-Xian Ren,Zhi Zhou,Wen-Kai Jiang,Min Yang

Drug design, development and therapy 17:691-706 PubMed36915642

2023

Integrated Network Pharmacology and Experimental Validation Approach to Investigate the Mechanisms of in the Treatment of Rheumatoid Arthritis.

Applications

Unspecified application

Species

Unspecified reactive species

Wendong Xie,Hua Yang,Chun Guo,Rui Xie,Guoliang Yu,Yifu Li

Life (Basel, Switzerland) 13: PubMed36836664

2023

Secukinumab and Black Garlic Downregulate OPG/RANK/RANKL Axis and Devitalize Myocardial Interstitial Fibrosis Induced by Sunitinib in Experimental Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Hoda E Mohamad,Mervat E Asker,Mohamed A Shaheen,Nourhan M Baraka,Omer I Fantoukh,Abdulaziz Alqahtani,Alaa E Salama,Yasmin K Mahmoud

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 10:e2205336 PubMed36581472

2022

Nitric Oxide-Releasing Bioinspired Scaffold for Exquisite Regeneration of Osteoporotic Bone via Regulation of Homeostasis.

Applications

Unspecified application

Species

Unspecified reactive species

Jun-Kyu Lee,Da-Seul Kim,So-Yeon Park,Seung-Woon Baek,Ji-Won Jung,Tae-Hyung Kim,Dong Keun Han

Journal of clinical medicine 12: PubMed36614859

2022

Effect of Mechanical Stimuli and Zoledronic Acid on the Femoral Bone Morphology in Rats with Obesity and Limited Mobility.

Applications

Unspecified application

Species

Unspecified reactive species

Nazar M Kostyshyn,Siemowit Muszyński,Ewa Tomaszewska,Agnieszka Tomczyk-Warunek,Iwona Puzio,Piotr Dobrowolski

Science advances 8:eabp8293 PubMed36525494

2022

In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Akash K Kaushik,Amy Tarangelo,Lindsey K Boroughs,Mukundan Ragavan,Yuanyuan Zhang,Cheng-Yang Wu,Xiangyi Li,Kristen Ahumada,Jui-Chung Chiang,Vanina T Tcheuyap,Faeze Saatchi,Quyen N Do,Cissy Yong,Tracy Rosales,Christina Stevens,Aparna D Rao,Brandon Faubert,Panayotis Pachnis,Lauren G Zacharias,Hieu Vu,Feng Cai,Thomas P Mathews,Giannicola Genovese,Barbara S Slusher,Payal Kapur,Xiankai Sun,Matthew Merritt,James Brugarolas,Ralph J DeBerardinis

Emergency medicine international 2022:1022078 PubMed37008288

2022

Abnormal Variations of the Key Genes in Osteoporotic Fractures.

Applications

Unspecified application

Species

Unspecified reactive species

Bin Wang,Caiyuan Mai,Lei Pan

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-RANKL antibody [C1]

Western blot - Anti-RANKL antibody [C1] (AB239607)

Western blot - Anti-RANKL antibody [C1] (AB239607)

Key facts

Host species

Clonality

Clone number

Isotype

Light chain type

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (21)

Alternative Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Complementary Products

Assay Kits

Primary Antibodies

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Product promise