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AB52562

Anti-RANTES antibody [VL1]

3

(1 Review)

|

(4 Publications)

Mouse Monoclonal RANTES antibody. Suitable for IP, ELISA, WB, IHC-Fr and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CCL5.

View Alternative Names

D17S136E, SCYA5, CCL5, C-C motif chemokine 5, EoCP, Eosinophil chemotactic cytokine, SIS-delta, Small-inducible cytokine A5, T cell-specific protein P228, T-cell-specific protein RANTES, TCP228

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

VL1

Isotype

IgG2b

Light chain type

kappa

Carrier free

No

Reacts with

Human

Applications

WB, IP, IHC-Fr, ELISA

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CCL5.

P13501

Specificity

Recognizes natural and recombinant human RANTES.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" } } }
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Product details

This antibody is useful for studies involving inhibition of chemotaxis and immunostaining of cryostat sections and cytospins.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Purification notes
Sterile filtered (0.22 micron). >95% by SDS-PAGE analysis.
Storage buffer
Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) (PubMed : 1380064, PubMed : 15923218, PubMed : 16791620, PubMed : 8525373, PubMed : 9516414). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed : 23979485).
See full target information CCL5
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Journal for immunotherapy of cancer 12: PubMed38886114

2024

EBV promotes TCR-T-cell therapy resistance by inducing CD163+M2 macrophage polarization and MMP9 secretion.

Applications

Unspecified application

Species

Unspecified reactive species

Yuanyuan Chen,Dijun Ouyang,Yan Wang,Qiuzhong Pan,Jingjing Zhao,Hao Chen,Xinyi Yang,Yan Tang,Qijing Wang,Yongqiang Li,Jia He,Jin-Qi You,Yingzi Li,Chi Xu,Yan Ren,Sisi Xie,Song Li,Jiamin Lian,Desheng Weng,Tong Xiang,Jian-Chuan Xia

Frontiers in genetics 14:1083615 PubMed36861127

2023

Identification of key candidate genes and pathways in rheumatoid arthritis and osteoarthritis by integrated bioinformatical analysis.

Applications

Unspecified application

Species

Unspecified reactive species

Huijing Huang,Xinyi Dong,Kaimin Mao,Wanwan Pan,Bin'en Nie,Lindi Jiang

Cell research 31:1072-1087 PubMed34239070

2021

Pericytes augment glioblastoma cell resistance to temozolomide through CCL5-CCR5 paracrine signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao-Ning Zhang,Kai-Di Yang,Cong Chen,Zhi-Cheng He,Qiang-Hu Wang,Hua Feng,Sheng-Qing Lv,Yan Wang,Min Mao,Qing Liu,Yao-Yao Tan,Wen-Ying Wang,Tian-Ran Li,Lin-Rong Che,Zhong-Yi Qin,Ling-Xiang Wu,Min Luo,Chun-Hua Luo,Yu-Qi Liu,Wen Yin,Chao Wang,Hai-Tao Guo,Qing-Rui Li,Bin Wang,Wei Chen,Shuang Wang,Yu Shi,Xiu-Wu Bian,Yi-Fang Ping

The American Journal of dermatopathology 31:475-9 PubMed19542925

2009

Resolution of CD8+ lymphomatoid papulosis after surgical excision of the type AB-thymoma.

Applications

Unspecified application

Species

Unspecified reactive species

Aieska de Souza,Lawrence E Gibson,David A Wada,Eunhee S Yi,Fabiola Medeiros,Michael J Camilleri,Rokea el-Azhary,Ivana N Micallef
View all publications
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