Anti-RAP1GDS1 antibody

Target data

Acts as a GEF (guanine nucleotide exchange factor) for the Rho family of small GTP-binding proteins (G proteins) that stimulates the dissociation of GDP to enable subsequent binding of GTP (PubMed : 11948427, PubMed : 1549351, PubMed : 20709748, PubMed : 28630045, PubMed : 30190425). Additionally, appears to chaperone the processing and/or trafficking of small GTPases containing a C-terminal polybasic region independently of GEF activity (PubMed : 20709748, PubMed : 21242305). Targets include RAP1A/RAP1B, RHOA, RHOB, RHOC, RAC1 and KRAS (PubMed : 11948427, PubMed : 1549351, PubMed : 20709748, PubMed : 24415755). Regulates mitochondrial dynamics by controlling RHOT function to promote mitochondrial fission during high calcium conditions (PubMed : 27716788). Able to promote the Ca(2+) release from the endoplasmic reticulum via both inositol trisphosphate (Ins3P) and ryanodine sensitive receptors leading to a enhanced mitochondrial Ca(2+) uptake (PubMed : 24349085).. Isoform 1. Acts as a GEF (guanine nucleotide exchange factor) for unprenylated RHOA (PubMed : 24415755, PubMed : 28630045, PubMed : 30190425). Chaperones the entry and passage of small GTPases through the prenylation pathway (PubMed : 20709748). Recognizes the last amino acid in the GTPase C-terminal CAAX motif with a preference for 'Leu' over 'Met', indicating involvement in the geranylgeranylation pathway (PubMed : 24415755).. Isoform 2. Acts as a GEF (guanine nucleotide exchange factor) for prenylated RHOA (PubMed : 21242305, PubMed : 28630045, PubMed : 30190425). Acts as a GEF for RHOC (PubMed : 21242305). Chaperones the downstream trafficking and/or processing of small newly prenylated GTPases (PubMed : 20709748). Escorts RAC1 to the nucleus (PubMed : 12551911).