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AB96293

Anti-RASGRP 4 antibody

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(3 Publications)

Rabbit Polyclonal RASGRP 4 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human RASGRP4 aa 100-200.

View Alternative Names

RAS guanyl-releasing protein 4, RASGRP4

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RASGRP 4 antibody (AB96293)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RASGRP 4 antibody (AB96293)

ab96293, at a 1/100 dilution, staining RASGRP 4 in paraffin embedded SW480 (Human colon adenocarcinoma) tissue by Immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human RASGRP4 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.

Q8TDF6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP (PubMed : 11880369, PubMed : 11956218, PubMed : 12493770, PubMed : 18024961). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting Ras-mediated activation of PIK3CG/PI3Kgamma to promote neutrophil functional responses (By similarity). In CD117(+) dendritic cells and mast cells, participates in an lipopolysaccharide (LPS)-activated signaling pathway that stimulates the production of interferon-gamma and other pro-inflammatory cytokines by natural killer (NK) cells (By similarity). May function in mast cell differentiation (PubMed : 11880369, PubMed : 11956218, PubMed : 12493770, PubMed : 18024961). Does not appear to be required for the development of B-cells, DC-cells, T-cells, or NK-cells (By similarity).
See full target information RASGRP4
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Open forum infectious diseases 9:ofac041 PubMed35198649

2022

RasGRP Exacerbates Lipopolysaccharide-Induced Acute Kidney Injury Through Regulation of ERK Activation.

Applications

Unspecified application

Species

Unspecified reactive species

Wen Tang,Lu Wang,Yan Liu,Dong Xiao

Cell communication and signaling : CCS 17:92 PubMed31409422

2019

The critical role of RasGRP4 in the growth of diffuse large B cell lymphoma.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Zhu,Chunyan Xia,Lin Wu,Yuxuan Zhang,Junling Liu,Yinan Chen,Jing Liu,Yongxin Xiao,Kai Nie,Liyu Huang,Ning Qu,Hong Yu

Cancer cell 31:685-696.e6 PubMed28486107

2017

RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma.

Applications

Unspecified application

Species

Unspecified reactive species

Xu Chen,Qiuxia Wu,Philippe Depeille,Peirong Chen,Sophie Thornton,Helen Kalirai,Sarah E Coupland,Jeroen P Roose,Boris C Bastian
View all publications
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Product promise

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