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AB168445

Anti-RBM38 antibody

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(2 Publications)

Mouse Polyclonal RBM38 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human RBM38.

View Alternative Names

RNPC1, SEB4, RBM38, RNA-binding protein 38, CLL-associated antigen KW-5, HSRNASEB, RNA-binding motif protein 38, RNA-binding region-containing protein 1, ssDNA-binding protein SEB4

1 Images
Western blot - Anti-RBM38 antibody (AB168445)
  • WB

Unknown

Western blot - Anti-RBM38 antibody (AB168445)

All lanes:

Western blot - Anti-RBM38 antibody (ab168445) at 1 µg/mL

Lane 1:

Transfected 293T cell lysate at 50 µg

Lane 2:

Non-transfected 293T cell lysate at 50 µg

Secondary

All lanes:

Goat Anti-mouse HRP at 1/2500 dilution

Predicted band size: 25 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human RBM38.

Q9H0Z9

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Alternative Products

Primary Antibodies

AB200403

Anti-RBM38 antibody - C-terminal

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Complementary Products

Secondary Antibodies

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Primary Antibodies

AB273052

Anti-ZWINT antibody [EPR23440-96] - BSA and Azide free

BOND RX™ Validated|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-ZWINT antibody [EPR23440-96] - BSA and Azide free (AB273052)

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Primary Antibodies

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Anti-Ku80 antibody [EPR3468]

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Primary Antibodies

AB157592

Anti-WASH1 antibody - C-terminal

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  • 5
  • 1
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RNA-binding motif protein 38 also known as RBM38 or RNPC1 is a protein that interacts with RNA to influence gene expression. RBM38 has a molecular mass of approximately 26 kDa. It is mainly found in human tissues with notable expression in the liver kidney and brain. This protein contains an RNA recognition motif (RRM) that helps it bind to target RNA molecules affecting their stability and translation.
Biological function summary

RBM38 participates in post-transcriptional regulation modulating the stability and translation of messenger RNAs (mRNAs). It does not function alone but associates with other ribonucleoprotein complexes to achieve its regulatory roles. Through its binding activity RBM38 can influence cell cycle progression and apoptosis by regulating mRNAs such as p53 and p21 which are key players in cell fate decisions.

Pathways

RBM38 is involved in the p53 signaling pathway which plays a critical role in cell cycle control and response to DNA damage. It associates with proteins like Mdm2 and p21 which are vital components of this pathway. Additionally RBM38 interacts with the MAPK pathway which is important for regulating responses to various extracellular stimuli and ensuring proper cellular functions like proliferation and differentiation.

RBM38 has been linked to cancer and neurodegenerative diseases. In cancer its interaction with p53 and Mdm2 influences tumor suppression activities affecting tumor development and progression. In neurodegenerative diseases RBM38's regulation of mRNA stability may impact the expression of proteins involved in neuron survival and repair. Abnormal RBM38 function can disrupt these processes contributing to disease pathology.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation.. (Microbial infection) Essential factor for the splicing of the pre-mRNAs of human parvovirus B19 (B19V) and for the expression of B19V 11-kDa protein, which enhances viral replication.
See full target information RBM38
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine (Cambridge, Mass.) 31:136 PubMed40234753

2025

Acidosis regulates immune progression in rheumatoid arthritis by promoting the expression of cytokines and co-stimulatory molecules in synovial fibroblasts.

Applications

Unspecified application

Species

Unspecified reactive species

Xuewen Qian,Zhuoyan Zai,Yuemin Tao,Huifang Lv,Mengjia Hao,Longbiao Zhang,Xiaoyue Zhang,Yayun Xu,Yihao Zhang,Feihu Chen

Cellular oncology (Dordrecht) 46:1493-1507 PubMed37219768

2023

TRIM17-mediated ubiquitination and degradation of RBM38 promotes cisplatin resistance in non-small cell lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Tian Zhong,Jing Zhang,Xingren Liu,Hongmin Li
View all publications
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Product promise

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