AB200403

Anti-RBM38 antibody - C-terminal

Name: Anti-RBM38 antibody - C-terminal (ab200403) | Abcam
Brand: Abcam Limited
SKU: AB200403
Price: 535 USD
Availability: InStock

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(10 Publications)

Rabbit Polyclonal RBM38 antibody. C-terminal. Suitable for IHC-P, WB and reacts with Human samples. Cited in 10 publications. Immunogen corresponding to Synthetic Peptide within Human RBM38.

View Alternative Names

RNPC1, SEB4, RBM38, RNA-binding protein 38, CLL-associated antigen KW-5, HSRNASEB, RNA-binding motif protein 38, RNA-binding region-containing protein 1, ssDNA-binding protein SEB4

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RBM38 antibody - C-terminal (AB200403)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RBM38 antibody - C-terminal (AB200403)

Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling RBM38 with ab200403 at 1/35 dilution.

Supplier Data

Western blot - Anti-RBM38 antibody - C-terminal (AB200403)

All lanes:

Western blot - Anti-RBM38 antibody - C-terminal (ab200403) at 1/200 dilution

All lanes:

Human heart tissue at 40 µg

Predicted band size: 25 kDa

true

Exposure time: 1min

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human RBM38. The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/25 - 1/100", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RNA-binding motif protein 38 also known as RBM38 or RNPC1 is a protein that interacts with RNA to influence gene expression. RBM38 has a molecular mass of approximately 26 kDa. It is mainly found in human tissues with notable expression in the liver kidney and brain. This protein contains an RNA recognition motif (RRM) that helps it bind to target RNA molecules affecting their stability and translation.

Biological function summary

RBM38 participates in post-transcriptional regulation modulating the stability and translation of messenger RNAs (mRNAs). It does not function alone but associates with other ribonucleoprotein complexes to achieve its regulatory roles. Through its binding activity RBM38 can influence cell cycle progression and apoptosis by regulating mRNAs such as p53 and p21 which are key players in cell fate decisions.

Pathways

RBM38 is involved in the p53 signaling pathway which plays a critical role in cell cycle control and response to DNA damage. It associates with proteins like Mdm2 and p21 which are vital components of this pathway. Additionally RBM38 interacts with the MAPK pathway which is important for regulating responses to various extracellular stimuli and ensuring proper cellular functions like proliferation and differentiation.

RBM38 has been linked to cancer and neurodegenerative diseases. In cancer its interaction with p53 and Mdm2 influences tumor suppression activities affecting tumor development and progression. In neurodegenerative diseases RBM38's regulation of mRNA stability may impact the expression of proteins involved in neuron survival and repair. Abnormal RBM38 function can disrupt these processes contributing to disease pathology.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation.. (Microbial infection) Essential factor for the splicing of the pre-mRNAs of human parvovirus B19 (B19V) and for the expression of B19V 11-kDa protein, which enhances viral replication.

See full target information RBM38

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Publications (10)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 15:6328 PubMed39068192

2024

High-throughput sensitive screening of small molecule modulators of microexon alternative splicing using dual Nano and Firefly luciferase reporters.

Applications

Unspecified application

Species

Unspecified reactive species

Andrew J Best,Ulrich Braunschweig,Mingkun Wu,Shaghayegh Farhangmehr,Adrian Pasculescu,Justin J Lim,Lim Caden Comsa,Mark Jen,Jenny Wang,Alessandro Datti,Jeffrey L Wrana,Sabine P Cordes,Rima Al-Awar,Hong Han,Benjamin J Blencowe

Cancers 15: PubMed37296859

2023

RBM38 Reverses Sorafenib Resistance in Hepatocellular Carcinoma Cells by Combining and Promoting lncRNA-GAS5.

Applications

Unspecified application

Species

Unspecified reactive species

Xing Gao,Cheng Lu,Ziyu Liu,Yan Lin,Julu Huang,Lu Lu,Shuanghang Li,Xi Huang,Minchao Tang,Shilin Huang,Ziqin He,Xiaomin She,Rong Liang,Jiazhou Ye

Circulation 147:1823-1842 PubMed37158107

2023

Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Kyu-Won Cho,Mark Andrade,Seongho Bae,Sangsung Kim,Jin Eyun Kim,Er Yearn Jang,Sangho Lee,Ahsan Husain,Roy L Sutliff,John W Calvert,Changwon Park,Young-Sup Yoon

eLife 12: PubMed37010266

2023

Single-cell RNA-seq of heart reveals intercellular communication drivers of myocardial fibrosis in diabetic cardiomyopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Li,Xinqi Lou,Yingjie Zha,Yinyin Qin,Jun Zha,Lei Hong,Zhanli Xie,Shudi Yang,Chen Wang,Jianzhong An,Zhenhao Zhang,Shigang Qiao

Frontiers in genetics 13:1097234 PubMed36704343

2023

A novel 9-gene signature for the prediction of postoperative recurrence in stage II/III colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Cheng Xin,Yi Lai,Liqiang Ji,Ye Wang,Shihao Li,Liqiang Hao,Wei Zhang,Ronggui Meng,Jun Xu,Yonggang Hong,Zheng Lou

Molecular cell 82:2982-2999.e14 PubMed35914530

2022

Systematic exploration of dynamic splicing networks reveals conserved multistage regulators of neurogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Hong Han,Andrew J Best,Ulrich Braunschweig,Nicholas Mikolajewicz,Jack Daiyang Li,Jonathan Roth,Fuad Chowdhury,Federica Mantica,Syed Nabeel-Shah,Guillermo Parada,Kevin R Brown,Dave O'Hanlon,Jiarun Wei,Yuxi Yao,Abdelrahman Abou Zid,Lim Caden Comsa,Mark Jen,Jenny Wang,Alessandro Datti,Thomas Gonatopoulos-Pournatzis,Robert J Weatheritt,Jack F Greenblatt,Jeffrey L Wrana,Manuel Irimia,Anne-Claude Gingras,Jason Moffat,Benjamin J Blencowe

Oncology letters 23:27 PubMed34868364

2021

RBM38 is negatively regulated by miR-320b and enhances Adriamycin resistance in breast cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Ke,Kan Ni,Huimin Xue,Jia Li

Environmental toxicology 36:2436-2447 PubMed34453780

2021

RNA-binding protein RBM38 inhibits colorectal cancer progression by partly and competitively binding to PTEN 3'UTR with miR-92a-3p.

Applications

Unspecified application

Species

Unspecified reactive species

Bugao Guan,Guangrun Li,Benhai Wan,Xiang Guo,Desong Huang,Jun Ma,Ping Gong,Jinbao Guo,Yanzhi Bu

Medical science monitor : international medical jo 26:e921389 PubMed32088727

2020

RNA Binding Protein RNPC1 Suppresses the Stemness of Human Endometrial Cancer Cells via Stabilizing MST1/2 mRNA.

Applications

Unspecified application

Species

Unspecified reactive species

XingMei Wu,YongHui Wang,WeiJuan Zhong,HuiFei Cheng,ZhiFeng Tian

International journal of clinical and experimental pathology 10:11130-11136 PubMed31966462

2017

RNA-binding protein RBM38 acts as a tumor suppressor in gastric cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Peng Wang,Jianchun Gu,Xiaowei Li,Qiang Wang,Yongbin Ding

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-RBM38 antibody - C-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RBM38 antibody - C-terminal (AB200403)

Western blot - Anti-RBM38 antibody - C-terminal (AB200403)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (10)

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