Rabbit Polyclonal RBM38 antibody. C-terminal. Suitable for IHC-P, WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human RBM38.
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Publications
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- Cancers 15:2023RBM38 Reverses Sorafenib Resistance in Hepatocellular Carcinoma Cells by Combining and Promoting lncRNA-GAS5.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXing Gao,Cheng Lu,Ziyu Liu,Yan Lin,Julu Huang,Lu Lu,Shuanghang Li,Xi Huang,Minchao Tang,Shilin Huang,Ziqin He,Xiaomin She,Rong Liang,Jiazhou YePubMed 37296859
- Frontiers in genetics 13:10972342023A novel 9-gene signature for the prediction of postoperative recurrence in stage II/III colorectal cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesCheng Xin,Yi Lai,Liqiang Ji,Ye Wang,Shihao Li,Liqiang Hao,Wei Zhang,Ronggui Meng,Jun Xu,Yonggang Hong,Zheng LouPubMed 36704343
- Oncology letters 23:272021RBM38 is negatively regulated by miR-320b and enhances Adriamycin resistance in breast cancer cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJing Ke,Kan Ni,Huimin Xue,Jia LiPubMed 34868364
- Medical science monitor : international medical jo 26:e9213892020RNA Binding Protein RNPC1 Suppresses the Stemness of Human Endometrial Cancer Cells via Stabilizing MST1/2 mRNA.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXingMei Wu et. al.PubMed 32088727
- International journal of clinical and experimental pathology 10:11130-111362017RNA-binding protein RBM38 acts as a tumor suppressor in gastric cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPeng Wang,Jianchun Gu,Xiaowei Li,Qiang Wang,Yongbin DingPubMed 31966462
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human RBM38. The exact immunogen used to generate this antibody is proprietary information. Database link Q9H0Z9
Reactivity data
Select an application| IHC-P | WB | |
|---|---|---|
| Human | Tested | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/25.00000 - 1/100.00000 | Notes Perform heat-mediated antigen retrieval before commencing with IHC staining protocol. |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/200.00000 - 1/1000.00000 | Notes - |
Associated Products
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Target data
Function
RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation. (Microbial infection) Essential factor for the splicing of the pre-mRNAs of human parvovirus B19 (B19V) and for the expression of B19V 11-kDa protein, which enhances viral replication.
Alternative names
RNPC1, SEB4, RBM38, RNA-binding protein 38, CLL-associated antigen KW-5, HSRNASEB, RNA-binding motif protein 38, RNA-binding region-containing protein 1, ssDNA-binding protein SEB4
Recommended products
Rabbit Polyclonal RBM38 antibody. C-terminal. Suitable for IHC-P, WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human RBM38.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human RBM38. The exact immunogen used to generate this antibody is proprietary information. Database link Q9H0Z9
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
RNA-binding motif protein 38 also known as RBM38 or RNPC1 is a protein that interacts with RNA to influence gene expression. RBM38 has a molecular mass of approximately 26 kDa. It is mainly found in human tissues with notable expression in the liver kidney and brain. This protein contains an RNA recognition motif (RRM) that helps it bind to target RNA molecules affecting their stability and translation.
- Biological function summary
RBM38 participates in post-transcriptional regulation modulating the stability and translation of messenger RNAs (mRNAs). It does not function alone but associates with other ribonucleoprotein complexes to achieve its regulatory roles. Through its binding activity RBM38 can influence cell cycle progression and apoptosis by regulating mRNAs such as p53 and p21 which are key players in cell fate decisions.
- Pathways
RBM38 is involved in the p53 signaling pathway which plays a critical role in cell cycle control and response to DNA damage. It associates with proteins like Mdm2 and p21 which are vital components of this pathway. Additionally RBM38 interacts with the MAPK pathway which is important for regulating responses to various extracellular stimuli and ensuring proper cellular functions like proliferation and differentiation.
- Associated diseases and disorders
RBM38 has been linked to cancer and neurodegenerative diseases. In cancer its interaction with p53 and Mdm2 influences tumor suppression activities affecting tumor development and progression. In neurodegenerative diseases RBM38's regulation of mRNA stability may impact the expression of proteins involved in neuron survival and repair. Abnormal RBM38 function can disrupt these processes contributing to disease pathology.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-RBM38 antibody - C-terminal (ab200403)
All lanes: Western blot - Anti-RBM38 antibody - C-terminal (ab200403) at 1/200 dilution
All lanes: Human heart tissue at 40 µg
Developed using the ECL technique.
Predicted band size: 25 kDa
Exposure time: 1min
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RBM38 antibody - C-terminal (ab200403)
Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling RBM38 with ab200403 at 1/35 dilution.
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