Anti-RBM7 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

RNA-binding protein 7 (RBM7) also known as RNA-binding motif protein 7 functions mechanically by binding to RNA. It plays a role in RNA processing and degradation. The protein has a molecular mass of approximately 30 kDa and is part of the cell's machinery that manages RNA. RBM7 is expressed in various tissues across the human body indicating a broad role in cellular functions.

Biological function summary

RBM7 interacts with several molecular components to participate in the nuclear exosome complex. This complex is important for RNA processing and degradation ensuring proper RNA maturation and stability within cells. RBM7 influences the processing of non-coding RNAs and the turnover of messenger RNA (mRNA) impacting gene expression levels. Its interaction with other RNA-binding proteins and exosomal subunits emphasizes its role in RNA-related processes within cells.

Pathways

The involvement of RBM7 extends to RNA surveillance and degradation pathways notably the exosome complex pathway. It maintains RNA quality control and stability. RBM7 works in conjunction with other exosomal proteins like EXOSC10 ensuring effective RNA decay. RBM7 indirectly influences gene expression regulation through these pathways signifying its contribution to cellular homeostasis and response to aberrant RNA.

Associated diseases and disorders

Alterations in RBM7 expression or function have been linked to neurodegenerative diseases and cancer. Its role in RNA processing may impact neuronal survival and the development of neurological conditions. RBM7's malfunction can lead to improper RNA turnover contributing to disease progression. In cancer RBM7's connection with the tumor suppressor protein TP53 highlights its involvement in the regulation of cell growth and apoptosis illustrating the protein's importance in maintaining cellular health.