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AB272612

Anti-RBMS3 antibody

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(1 Publication)

Rabbit Polyclonal RBMS3 antibody. Suitable for IHC-P, ICC, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RBMS3 aa 300-450.

View Alternative Names

RBMS3

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RBMS3 antibody (AB272612)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RBMS3 antibody (AB272612)

Paraffin-embedded formalin-fixed human cerebellum tissue stained for RBMS3 using ab272612 at 1/200 in immunohistochemical analysis.

Immunocytochemistry - Anti-RBMS3 antibody (AB272612)
  • ICC

Unknown

Immunocytochemistry - Anti-RBMS3 antibody (AB272612)

PFA fixed, Triton X-100 permeabilized U-2 OS (Human bone osteosarcoma epithelial cell line) labeling RBMS3 (green) using ab272612at 2 ug/ml in ICC/IF analysis.

Western blot - Anti-RBMS3 antibody (AB272612)
  • WB

Supplier Data

Western blot - Anti-RBMS3 antibody (AB272612)

All lanes:

Western blot - Anti-RBMS3 antibody (ab272612) at 0.4 µg/mL

Lane 1:

U-2 OS (human bone osteosarcoma epithelial cell line) whole cell lysate

Lane 2:

HEK-293 (human epithelial cell line from embryonic kidney) whole cell lysate

Predicted band size: 48 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P, ICC

applications

Immunogen

Recombinant Fragment Protein within Human RBMS3 aa 300-450. The exact immunogen used to generate this antibody is proprietary information.

Q6XE24

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICC-species-checked": "testedAndGuaranteed", "ICC-species-dilution-info": "", "ICC-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100</p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RBMS3 also known as RNA-binding motif single-stranded interacting protein 3 is a protein with an approximate mass of 48 kDa. It is characterized by its RNA-binding motifs that enable interaction with single-stranded DNA and RNA. RBMS3 shows expression in various tissues notably in the heart lung and liver indicating a broad physiological role. The protein functions as a regulator of gene expression by binding to specific nucleic acid sequences influencing the stability and translation of mRNA.
Biological function summary

The functions performed by RBMS3 involve regulation in the cell cycle particularly in the control of cell proliferation and differentiation. It forms part of the complex that manages cellular responses to different physiological signals. Through its binding capacity RBMS3 influences the stability of critical mRNA transcripts involved in cellular growth and survival. This action places it at an essential point for maintaining normal cellular functions and adaptations to changes in the cellular environment.

Pathways

Its influence extends across several biological pathways including cell growth and apoptosis. RBMS3 regulates pathways involving tumor suppressors and oncogenes closely working with proteins such as p53 to control abnormal cell growth. In DNA damage response pathways RBMS3 affects how cells react to stressors that can lead to genetic mutations linking it to essential regulatory networks that maintain genomic integrity.

RBMS3 has been associated with cancer progression and developmental abnormalities. It frequently appears in research focusing on gastric and breast cancer where its function or expression levels change. In these contexts RBMS3 interacts with other regulatory proteins such as MYC which are involved in tumorigenesis. Disruptions in the regulation by RBMS3 may lead to uncontrolled cellular growth highlighting its role in disease pathology and potential as a therapeutic target.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Binds poly(A) and poly(U) oligoribonucleotides.
See full target information RBMS3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cancer medicine 13:e7129 PubMed38618967

2024

The RNA-binding protein RBMS3 inhibits the progression of colon cancer by regulating the stability of LIMS1 mRNA.

Applications

Unspecified application

Species

Unspecified reactive species

Yafei Li,Shuoshuo Wang,Guoli Li,Chunyang Gao,Zihan Cui,Mingqi Cong,Jie Hu,Minghui Zhang,Xiaoming Jin,Haiying Sun,Dan Kong
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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