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AB154881

Anti-RBP1 antibody

5

(2 Reviews)

|

(7 Publications)

Rabbit Polyclonal RET1 antibody. Suitable for WB and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human RBP1 aa 1 to C-terminus.

View Alternative Names

CRBP1, RBP1, Retinol-binding protein 1, Cellular retinol-binding protein, Cellular retinol-binding protein I, CRBP, CRBP-I

1 Images
Western blot - Anti-RBP1 antibody (AB154881)
  • WB

Supplier Data

Western blot - Anti-RBP1 antibody (AB154881)

Samples were separated by 12% SDS-PAGE.

All lanes:

Western blot - Anti-RBP1 antibody (ab154881) at 1/5000 dilution

All lanes:

SH SY 5Y Whole cell extract at 30 µg

Secondary

All lanes:

HRP conjugated anti rabbit IgG antibody

Predicted band size: 16 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human RBP1 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P09455

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Retinol binding protein 1 (RBP1) also known as cellular retinol-binding protein 1 (CRBP1) plays a critical role in the regulation and transportation of retinol a form of vitamin A within cells. RBP1 has a molecular mass of approximately 15 kDa and localizes predominantly in the cytoplasm. It is expressed in multiple tissues including the liver kidney and adipose tissue where it helps in regulating retinoid metabolism. The presence of RBP1 in these tissues is essential for maintaining physiological retinol levels.
Biological function summary

RBP1 assists in the cellular uptake storage and metabolism of retinol facilitating its conversion into retinal and retinoic acid. Although it is not part of a well-defined complex RBP1 works closely with enzymes involved in retinol metabolism such as lecithin retinol acyltransferase (LRAT) and retinal dehydrogenases. This process is important for maintaining visual function immune response and cellular differentiation which all rely on proper retinol metabolism and activity.

Pathways

RBP1 plays a significant role in the retinoic acid signaling pathway affecting gene expression regulation by modulating retinoid concentrations. It interacts with retinoic acid receptor (RAR) and retinoid X receptor (RXR) pathways influencing transcriptional activities related to development and differentiation. Connections between RBP1 and LRAT are important for the retinol esterification process integrating into broader retinoid metabolism and signaling pathways that govern cellular functions.

Dysregulation of RBP1 can contribute to conditions such as age-related macular degeneration (AMD) and metabolic syndrome. In AMD impaired retinol transport and metabolism lead to retinal damage and vision loss. In metabolic syndrome altered retinoid homeostasis involving RBP1 may exacerbate insulin resistance and obesity. Relationships with proteins like LRAT and retinaldehyde dehydrogenase (RALDH) highlight its involvement in disease mechanisms related to retinol dysfunction.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Cytoplasmic retinol-binding protein (PubMed : 22665496, PubMed : 26900151, PubMed : 28057518). Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis (PubMed : 15632377, PubMed : 22665496).
See full target information RBP1
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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

Science advances 10:eadr3530 PubMed39693423

2024

Regional differences in three-dimensional fiber organization, smooth muscle cell phenotype, and contractility in the pregnant mouse cervix.

Applications

Unspecified application

Species

Unspecified reactive species

Christopher J Hansen,Jackson H Rogers,Alexus J Brown,Naoko Boatwright,Shajila Siricilla,Christine M O'Brien,Sourav Panja,Cameron M Nichols,Kanchana Devanathan,Benjamin M Hardy,Mark D Does,Adam W Anderson,Bibhash C Paria,Anita Mahadevan-Jansen,Jeff Reese,Jennifer L Herington

Cellular signalling :109950 PubMed33582185

2021

WITHDRAWN: Circ_0000517 contributes to hepatocellular carcinoma progression by upregulating ARID4B via sponging miR-328-3p.

Applications

Unspecified application

Species

Unspecified reactive species

Yongmei Zhao,Ya Sun,Jing Yang,Zhenfeng Zhu,Xin Jia

Frontiers in cellular neuroscience 14:123 PubMed32528249

2020

Cell-Specific Transcriptional Responses to Heat Shock in the Mouse Utricle Epithelium.

Applications

Unspecified application

Species

Unspecified reactive species

Erica Sadler,Matthew M Ryals,Lindsey A May,Daniel Martin,Nora Welsh,Erich T Boger,Robert J Morell,Ronna Hertzano,Lisa L Cunningham

Scientific reports 10:3850 PubMed32123215

2020

Hepatic stellate cell hypertrophy is associated with metabolic liver fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Céline Hoffmann,Nour El Houda Djerir,Anne Danckaert,Julien Fernandes,Pascal Roux,Christine Charrueau,Anne-Marie Lachagès,Frédéric Charlotte,Isabelle Brocheriou,Karine Clément,Judith Aron-Wisnewsky,Fabienne Foufelle,Vlad Ratziu,Bernard Hainque,Dominique Bonnefont-Rousselot,Pascal Bigey,Virginie Escriou

Human molecular genetics : PubMed30986821

2019

The protective variant rs7173049 at LOXL1 locus impacts on retinoic acid signaling pathway in pseudoexfoliation syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Daniel Berner,Ursula Hoja,Matthias Zenkel,James Julian Ross,Steffen Uebe,Daniela Paoli,Paolo Frezzotti,Robyn M Rautenbach,Ari Ziskind,Susan E Williams,Trevor R Carmichael,Michele Ramsay,Fotis Topouzis,Anthi Chatzikyriakidou,Alexandros Lambropoulos,Periasamy Sundaresan,Humaira Ayub,Farah Akhtar,Raheel Qamar,Juan C Zenteno,Marisa Cruz-Aguilar,Yury S Astakhov,Michael Dubina,Janey Wiggs,Mineo Ozaki,Friedrich E Kruse,Tin Aung,André Reis,Chiea Chuen Khor,Francesca Pasutto,Ursula Schlötzer-Schrehardt

The Journal of biological chemistry 292:15080-15093 PubMed28733465

2017

The retinol-binding protein receptor STRA6 regulates diurnal insulin responses.

Applications

Unspecified application

Species

Unspecified reactive species

Christy M Gliniak,J Mark Brown,Noa Noy

Journal of ophthalmology 2015:918473 PubMed26124962

2015

iTRAQ-Based Proteomic Analysis of Visual Cycle-Associated Proteins in RPE of rd12 Mice before and after RPE65 Gene Delivery.

Applications

WB

Species

Unspecified reactive species

Qinxiang Zheng,Yueping Ren,Radouil Tzekov,Shanshan Hua,Minghan Li,Jijing Pang,Jia Qu,Wensheng Li
View all publications
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Product promise

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