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AB233514

Anti-RBP2 antibody

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(1 Publication)

Rabbit Polyclonal RET2 antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat, Pig, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human RBP2.

View Alternative Names

CRBP2, RBP2, Retinol-binding protein 2, Cellular retinol-binding protein II, CRBP-II

5 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RBP2 antibody (AB233514)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RBP2 antibody (AB233514)

Formalin-fixed, paraffin-embedded human rectum tissue stained for RBP2 using ab233514 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Western blot - Anti-RBP2 antibody (AB233514)
  • WB

Supplier Data

Western blot - Anti-RBP2 antibody (AB233514)

All lanes:

Western blot - Anti-RBP2 antibody (ab233514) at 2 µg/mL

All lanes:

Rat small intestine lysate

Predicted band size: 16 kDa

false

Western blot - Anti-RBP2 antibody (AB233514)
  • WB

Supplier Data

Western blot - Anti-RBP2 antibody (AB233514)

All lanes:

Western blot - Anti-RBP2 antibody (ab233514) at 2 µg/mL

All lanes:

Recombinant human RBP2 protein

Predicted band size: 16 kDa

false

Western blot - Anti-RBP2 antibody (AB233514)
  • WB

Supplier Data

Western blot - Anti-RBP2 antibody (AB233514)

All lanes:

Western blot - Anti-RBP2 antibody (ab233514) at 2 µg/mL

All lanes:

Mouse small intestine lysate

Predicted band size: 16 kDa

false

Western blot - Anti-RBP2 antibody (AB233514)
  • WB

Supplier Data

Western blot - Anti-RBP2 antibody (AB233514)

All lanes:

Western blot - Anti-RBP2 antibody (ab233514) at 2 µg/mL

All lanes:

Pig small intestine lysate

Predicted band size: 16 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human, Pig

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human RBP2.

P50120

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RBP2 also known as KDM5A or Lysine Demethylase 5A functions as a histone demethylase enzyme specific for H3K4me3 and H3K4me2. With a mass of about 175 kDa it influences chromatin structure by removing methyl groups from histones which affects gene transcription. This protein expresses in various tissues especially in those with rapid cell division such as embryonic stem cells and certain cancer cell lines.
Biological function summary

RBP2 contributes to the regulation of gene expression by modifying chromatin accessibility. It forms part of transcriptional complexes that involve other chromatin-remodeling proteins. Through its demethylase activity RBP2 regulates the transcriptional response to different cellular signals and contributes to processes like cell cycle progression and differentiation.

Pathways

RBP2 plays a significant role in chromatin organization and transcriptional regulation pathways. RBP2 interacts closely with other chromatin-modifying proteins such as the Polycomb group of proteins impacting the Rb-E2F pathway involved in cell cycle control. This interaction influences whether cells proceed to division or undergo differentiation making it essential for maintaining proper cell growth and development.

RBP2 has connections to cancer and developmental disorders. Its abnormal expression often associates with various cancers including leukemia and breast cancer contributing to uncontrolled cell proliferation and tumor growth. In these contexts RBP2 may interact with proteins like pRB and E2F which are important in cell cycle regulation highlighting its importance in cancer biology. Additionally mutations in RBP2 can result in developmental abnormalities further highlighting its critical role in normal cellular processes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Intracellular transport of retinol.
See full target information RBP2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11:e2402299 PubMed39316370

2024

Embryo-Derived Cathepsin B Promotes Implantation and Decidualization by Activating Pyroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Meng-Yuan Li,Ying Wu,Hao-Lan Tang,Ying Wang,Bo Li,Yu-Ying He,Gui-Jun Yan,Zeng-Ming Yang
View all publications
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Product promise

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