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AB233190

Anti-RBP3/IRBP antibody

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Rabbit Polyclonal Retinol binding protein 3 antibody. Suitable for WB and reacts with Mouse, Human samples.

View Alternative Names

Rbp3

2 Images
Western blot - Anti-RBP3/IRBP antibody (AB233190)
  • WB

Supplier Data

Western blot - Anti-RBP3/IRBP antibody (AB233190)

All lanes:

Western blot - Anti-RBP3/IRBP antibody (ab233190) at 2 µg/mL

All lanes:

Recombinant rat RBP3/IRBP protein fragment, comprised of residues 422 – 601, with an N-terminal His tag

Predicted band size: 135 kDa

false

Western blot - Anti-RBP3/IRBP antibody (AB233190)
  • WB

Supplier Data

Western blot - Anti-RBP3/IRBP antibody (AB233190)

All lanes:

Western blot - Anti-RBP3/IRBP antibody (ab233190) at 1 µg/mL

All lanes:

Mouse eye tissue lysate.

Predicted band size: 135 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: 55.77% Glycerol (glycerin, glycerine), 44.219% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The RBP3 protein also known as Interphotoreceptor Retinoid-Binding Protein (IRBP) plays a significant mechanical role in the eye. This protein is characterized by a mass of approximately 135 kDa and is primarily expressed in the retina and vitreous body. RBP3 is involved in the transport and protection of retinoids between the photoreceptor cells and the retinal pigment epithelium. It facilitates the movement of molecules necessary for the visual cycle ensuring efficient communication between different cellular components of the eye.
Biological function summary

RBP3 is integral in maintaining retinal health aiding the regeneration of visual pigments and the function of photosensitive cells. It does not appear to be part of a larger complex but operates independently within the extracellular space between the retina cells. The protein binds retinoids including retinol and retinaldehyde which are critical for converting light into visual signals. This function supports the overall visual transduction pathway in vertebrates.

Pathways

RBP3 is an important player in the visual cycle pathway maintaining normal vision by aiding in the synthesis and recycling of visual pigments. It works closely with proteins like opsin which is involved in the photoactivation required for vision. Furthermore RBP3 interacts within the retinoid cycle in the retina ensuring that retinoids are efficiently recycled and available for phototransduction.

RBP3 has connections with retinitis pigmentosa and age-related macular degeneration both of which are severe degenerative disorders of the retina. Mutations or deficiencies in RBP3 can disrupt retinoid transport leading to impaired vision or vision loss. This protein may be linked to other visual cycle proteins such as RPE65 which also play roles in the development of these diseases. Understanding RBP3's function and interaction with other proteins helps in developing therapeutic strategies for these retinal conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Retinol binding protein 3
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Product promise

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