AB122667

Anti-RCCD1 antibody

Name: Anti-RCCD1 antibody (ab122667) | Abcam
Brand: Abcam Limited
SKU: AB122667
Price: 545 USD
Availability: InStock

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(1 Publication)

Rabbit Polyclonal RCCD1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RCCD1 aa 250 to C-terminus.

View Alternative Names

RCC1 domain-containing protein 1, RCCD1

6 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RCCD1 antibody (AB122667)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RCCD1 antibody (AB122667)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human skin tissue labeling RCCD1 with ab122667 at 1/200.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RCCD1 antibody (AB122667)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human testis tissue labeling RCCD1 with ab122667 at 1/200.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RCCD1 antibody (AB122667)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human small intestine tissue labeling RCCD1 with ab122667 at 1/200.

Immunocytochemistry/ Immunofluorescence - Anti-RCCD1 antibody (AB122667)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-RCCD1 antibody (AB122667)

ab122667, at 4 μg/ml staining RCCD1 in PFA/Triton X-100 fixed/permeabilized A431 cells by Immunofluorescence (green).

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RCCD1 antibody (AB122667)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human fallopian tube tissue labeling RCCD1 with ab122667 at 1/200.

Supplier Data

Western blot - Anti-RCCD1 antibody (AB122667)

All lanes:

Western blot - Anti-RCCD1 antibody (ab122667)

Lane 1:

Marker

Lane 2:

HEK293T cell lysate - vector only transfected

Lane 3:

HEK293T cell lysate - overexpressing RCCD1 with a C-terminal myc-DDK tag (~3.1kDa)

Predicted band size: 40 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human RCCD1 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

A6NED2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": " Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RCCD1 also known as RCG1 or RCG1A is a pivotal protein involved in regulating various cellular processes. It weighs approximately 28 kDa and primarily localizes in the nucleus. RCCD1 expression mainly occurs in tissues such as the brain and testes suggesting its importance in these specific sites. The protein interacts with other cellular components to carry out its functions effectively particularly playing a role in cellular division and growth regulation.

Biological function summary

RCCD1 integrates into the chromatin remodeling complex acting as an important modulator of transcriptional regulation. It serves to influence gene expression by modifying chromatin structure which impacts DNA accessibility. By participating in such complexes RCCD1 enables cellular adaptation to different growth conditions and stress responses. This protein ensures proper function and regulation of genes essential for cell survival and proliferation.

Pathways

RCCD1 contributes to the Wnt signaling pathway which heavily relies on interaction with the beta-catenin protein. The involvement in Wnt signaling indicates RCCD1's role in guiding cell fate decisions influencing processes like cell growth and differentiation. In addition RCCD1 aligns with the Notch signaling pathway associating with proteins such as Notch1 to regulate lateral inhibition and boundary formation during development.

RCCD1 exhibits connections with certain cancers notably colorectal cancer. The abnormal regulation of RCCD1 affects the Wnt signaling pathway often leading to uncontrolled cell proliferation related to tumorigenesis. RCCD1 also links with neurological disorders where its dysregulation impacts brain development and function possibly associating with proteins such as APP in Alzheimer's disease. These associations highlight the significant relevance of RCCD1 in disease progression and pathological outcomes.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8 (PubMed : 24981860). Possibly together with KDM8, is involved in proper mitotic spindle organization and chromosome segregation (PubMed : 24981860). Plays a role in regulating alpha-tubulin deacetylation and cytoskeletal microtubule stability, thereby promoting cell migration and TGF-beta-induced epithelial to mesenchymal transition (EMT), potentially through the inhibition of KDM8 (PubMed : 28455245).

See full target information RCCD1

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Virologica Sinica 39:501-512 PubMed38789039

2024

Calmodulin-like 5 promotes PEDV replication by regulating late-endosome synthesis and innate immune response.

Applications

Unspecified application

Species

Unspecified reactive species

Wen-Jun Tian,Xiu-Zhong Zhang,Jing Wang,Jian-Feng Liu,Fu-Huang Li,Xiao-Jia Wang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-RCCD1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RCCD1 antibody (AB122667)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RCCD1 antibody (AB122667)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RCCD1 antibody (AB122667)

Immunocytochemistry/ Immunofluorescence - Anti-RCCD1 antibody (AB122667)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RCCD1 antibody (AB122667)

Western blot - Anti-RCCD1 antibody (AB122667)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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