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AB254802

Anti-RDM1 antibody

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(1 Publication)

Rabbit Polyclonal RDM1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RDM1 aa 50 to C-terminus.

View Alternative Names

RAD52B, RDM1, RAD52 motif-containing protein 1, RAD52 homolog B

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-RDM1 antibody (AB254802)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-RDM1 antibody (AB254802)

PFA fixed, Triton X-100 permeabilized A-431 (Human epidermoid carcinoma cell line) cells labeling RDM1 using ab254802 at 4µg/ml (green) in ICC/IF.

Western blot - Anti-RDM1 antibody (AB254802)
  • WB

Supplier Data

Western blot - Anti-RDM1 antibody (AB254802)

All lanes:

Western blot - Anti-RDM1 antibody (ab254802) at 0.4 µg/mL

Lane 1:

Vector only transfected HEK-293T cell lysate

Lane 2:

RDM1 overexpressed HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate

Predicted band size: 31 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human RDM1 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8NG50

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Alternative Products

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Complementary Products

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Proteins & Peptides

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AB254733

Anti-SFRS11 antibody

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Cynomolgus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RDM1 also called RAD52 motif 1 is a protein that facilitates DNA repair processes. It has a molecular weight of approximately 41 kDa and appears in diverse tissues throughout the body. Researchers note its expression in the nucleus where it engages in repairing DNA breaks ensuring genomic stability. As part of a family of proteins involved in DNA repair RDM1 shares structural components but stands out due to specific motif involvement.
Biological function summary

RDM1 aids in the restoration of damaged DNA and participates in homologous recombination repair. It forms part of a complex that detects and responds to DNA damage contributing to cell cycle regulation. By working together with proteins like RAD52 RDM1 reinforces the cellular ability to manage genetic lesions enabling cells to maintain growth and replication integrity under stress conditions.

Pathways

The actions of RDM1 are integral to the DNA damage response pathway. This pathway links to mechanisms that control cell cycle checkpoints. The protein intersects with the homologous recombination repair pathway cooperating with other essential proteins such as BRCA2. These alliances highlight RDM1's role in shaping effective responses to genomic injury facilitating accurate DNA repair and preventing mutations.

Aberrations involving RDM1 have connections to cancer progression. Disruptions in its function lead to deficiencies in DNA repair and increased genetic instability contributing to tumorigenesis. Additionally RDM1-associated malfunction may also relate to neurodegenerative disorders given oxidative stress impacts DNA integrity. In cancer it shares interactions with proteins such as RAD51 highlighting its involvement in robust genomic maintenance.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA.
See full target information RDM1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

World journal of surgical oncology 19:246 PubMed34404391

2021

Identification of a novel circ_0018289/miR-183-5p/TMED5 regulatory network in cervical cancer development.

Applications

Unspecified application

Species

Unspecified reactive species

Heng Zou,Huijia Chen,Shuaibin Liu,Xiaoling Gan
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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