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AB190658

Anti-REBOV GP antibody

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(1 Publication)

Rabbit Polyclonal REBOV GP antibody. Carrier free. Suitable for WB and reacts with Recombinant fragment - Reston ebolavirus samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Reston ebolavirus - Reston (1989) GP.

View Alternative Names

Pre-small/secreted glycoprotein, pre-sGP, GP

2 Images
Western blot - Anti-REBOV GP antibody (AB190658)
  • WB

Supplier Data

Western blot - Anti-REBOV GP antibody (AB190658)

REBOV GP is visualized as a broad band representing differing glycosylation patterns.

All lanes:

Western blot - Anti-REBOV GP antibody (ab190658) at 0.5 µg/mL

Lane 1:

REBOV rGPdTM supernatant at 15 µL

Lane 2:

ZEBOV rGPdTM at 0.2 µg

Lane 3:

SEBOV rGPdTM at 0.2 µg

Lane 4:

MARV rGPdTM at 0.2 µg

Lane 5:

BEBOV rGPdTM at 0.2 µg

Predicted band size: 42 kDa

false

Western blot - Anti-REBOV GP antibody (AB190658)
  • WB

Supplier Data

Western blot - Anti-REBOV GP antibody (AB190658)

REBOV GP is visualized as a broad band representing differing glycosylation patterns.

All lanes:

Western blot - Anti-REBOV GP antibody (ab190658) at 0.05 µg/mL

Lane 1:

REBOV rGPdTM supernatant at 15 µL

Lane 2:

ZEBOV rGPdTM at 0.2 µg

Lane 3:

SEBOV rGPdTM at 0.2 µg

Lane 4:

MARV rGPdTM at 0.2 µg

Lane 5:

BEBOV rGPdTM at 0.2 µg

Predicted band size: 42 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Reston ebolavirus

Applications

WB

applications

Immunogen

Synthetic Peptide within Reston ebolavirus - Reston (1989) GP. The exact immunogen used to generate this antibody is proprietary information.

Q66800

Specificity

ab190658 detects recombinant REBOV GP without the transmembrane region (REBOV rGPdTM). No cross reactivity to Sudan ebolavirus (SEBOV) GP, Zaire ebolavirus (ZEBOV) GP, Bundibugyo (BEBOV) GP or Marburg (MARV) GP, was observed in Western blot analysis.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Recombinant fragment - Reston ebolavirus": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5 µg/mL", "WB-species-notes": "<p></p>" }, "Reston ebolavirus": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

REBOV GP also known as Reston virus glycoprotein is a critical structural protein of the Reston virus. This glycoprotein approximately 150 kDa in mass plays a role in viral attachment and entry into host cells. It is expressed on the surface of the virus envelope facilitating interaction with host cell receptors. The membrane-bound form is often essential for the virus's ability to invade host cells influencing virulence and pathogenicity.
Biological function summary

The Reston virus glycoprotein mediates the fusion process of the viral envelope with the host cell membrane. It is part of a complex that includes stable interactions with other viral proteins necessary for replication. This interaction is key for ensuring viral propagation within if not outside its natural reservoirs and host organisms.

Pathways

Reston virus glycoprotein facilitates entry into the host cell through the endocytosis pathway. It closely interacts with cellular receptors such as NPC1 affecting how the virus exploits host cellular machinery for entry and replication. Other viral proteins collaborate or compete in these pathways to enable the virus's lifecycle to proceed efficiently.

Reston virus glycoprotein associates with hemorrhagic fevers mainly when Reston virus crosses species barriers from natural hosts. While it has not caused significant disease in humans potential zoonotic transmission remains a concern. The glycoprotein's interaction with the immune regulatory protein TIM-1 may influence disease severity and progression in the host.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Small/secreted glycoprotein. Seems to possess an anti-inflammatory activity as it can reverse the barrier-decreasing effects of TNF alpha. Might therefore contribute to the lack of inflammatory reaction seen during infection in spite the of extensive necrosis and massive virus production. Does not seem to be involved in activation of primary macrophages. Does not seem to interact specifically with neutrophils.. Delta-peptide. Viroporin that permeabilizes mammalian cell plasma membranes. It acts by altering permeation of ionic compounds and small molecules. This activity may lead to viral enterotoxic activity.
See full target information GP
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Virology journal 20:128 PubMed37337294

2023

Comparative characterization of Crimean-Congo hemorrhagic fever virus cell culture systems with application to propagation and titration methods.

Applications

Unspecified application

Species

Unspecified reactive species

Hongzhao Li,Greg Smith,Melissa Goolia,Peter Marszal,Bradley S Pickering
View all publications
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Product promise

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