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AB22492

Anti-RECA1 antibody [HIS52]

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(19 Publications)

Mouse Monoclonal Rad51 antibody. Suitable for IHC-P, ICC/IF, IHC-Fr and reacts with Rat samples. Cited in 19 publications. Immunogen corresponding to Cell preparation containing RECA1 protein.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

HIS52

Isotype

IgG1

Carrier free

No

Reacts with

Rat

Applications

IHC-P, ICC/IF, IHC-Fr

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

This antibody recognises RecA-1, a cell surface antigen which is expressed by all rat endothelial cells.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IHCFr-species-checked": "notRecommended", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p>Fix with acetone.</p>" }, "Rat": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p>Fix with acetone.</p>" }, "Chicken": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IHCFr-species-checked": "notRecommended", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p>Fix with acetone.</p>" }, "Goat": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IHCFr-species-checked": "notRecommended", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p>Fix with acetone.</p>" }, "Guinea pig": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IHCFr-species-checked": "notRecommended", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p>Fix with acetone.</p>" }, "Pig": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IHCFr-species-checked": "notRecommended", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p>Fix with acetone.</p>" }, "Rabbit": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IHCFr-species-checked": "notRecommended", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p>Fix with acetone.</p>" }, "Sheep": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IHCFr-species-checked": "notRecommended", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p>Fix with acetone.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
Preservative: 0.09% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RECA1 also known as Recombinase A1 is a protein with a molecular mass of approximately 37 kDa. This protein performs an important role in DNA repair and homologous recombination. RECA1 operates by promoting the alignment of homologous DNA strands and facilitating the exchange of DNA strands. It is expressed in various tissues with higher levels observed in actively dividing cells where DNA repair is critical. Its activity is important for maintaining genomic integrity and ensuring proper cell division.
Biological function summary

RECA1 supports cellular DNA repair mechanisms addressing damaged DNA and preventing mutations from propagating. As part of the homologous recombination complex it assists in precise DNA repair by enabling the search for homology and strand pairing. This function enables cells to accurately repair double-strand breaks which are a severe form of DNA damage. This activity is essential for cell survival and avoiding chromosomal aberrations.

Pathways

RECA1 integrates into key molecular pathways involved in DNA damage response and repair such as the homologous recombination pathway. Within this pathway it interacts with proteins like RAD51 to facilitate accurate DNA strand exchange. Another important pathway is the p53 signaling pathway where RECA1 influences the cellular response to DNA damage by working alongside p53. This collaboration ensures proper regulation of the cell cycle and activation of apoptosis if repair fails.

RECA1 plays a significant role in cancer and genetic disorders characterized by genomic instability. Mutations or altered expression of RECA1 can lead to defective DNA repair mechanisms contributing to unregulated cell growth and cancer particularly ovarian and breast cancers. In genetic disorders like Bloom syndrome where genomic instability is evident deficiencies in RECA1-related pathways often exacerbate the disease. RECA1's interaction with RAD51 and other DNA repair proteins makes it a potential target for therapeutic interventions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information RECA1
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Publications (19)

Recent publications for all applications. Explore the full list and refine your search

Stem cell research & therapy 15:503 PubMed39736729

2024

A chitosan/acellular matrix-based neural graft carrying mesenchymal stem cells to promote peripheral nerve repair.

Applications

Unspecified application

Species

Unspecified reactive species

Zhifa Zhang,Molin Li,Gang Cheng,Peng Wang,Chunhui Zhou,Yang Liu,Xiaofeng Duan,Jing Wang,Fang Xie,Yaqiong Zhu,Jianning Zhang

Journal of biochemical and molecular toxicology 37:e23422 PubMed37350538

2023

Melatonin attenuates monocrotaline-induced hepatic sinusoidal obstruction syndrome in rats via activation of Sirtuin-3.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaofei Ren,Kui Xu,Jianming Xu,Qiao Mei

Journal of orthopaedic surgery and research 18:383 PubMed37231424

2023

Screening for autophagy/hypoxia/ferroptosis/pyroptosis-related genes of tendon injury and repair in a rat model after celecoxib and lactoferrin treatment.

Applications

Unspecified application

Species

Unspecified reactive species

Yaonan Zhang,Lei Shi,Fei Wang,Lin Wang,Nan Min,Liangyuan Wen,Qingyun Xue

Bioengineering & translational medicine 8:e10448 PubMed36925694

2023

Spinal cord tissue engineering using human primary neural progenitor cells and astrocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Chen Jin,Yayu Wu,Haipeng Zhang,Bai Xu,Wenbin Liu,Chunnan Ji,Panpan Li,Zhenni Chen,Bing Chen,Jiayin Li,Xianming Wu,Peipei Jiang,Yali Hu,Zhifeng Xiao,Yannan Zhao,Jianwu Dai

PloS one 17:e0269564 PubMed36018859

2022

Role of endoplasmic reticulum stress in impaired neonatal lung growth and bronchopulmonary dysplasia.

Applications

Unspecified application

Species

Unspecified reactive species

Kirkwood A Pritchard,Xigang Jing,Michelle Teng,Clive Wells,Shuang Jia,Adeleye J Afolayan,Jason Jarzembowski,Billy W Day,Stephen Naylor,Martin J Hessner,G Ganesh Konduri,Ru-Jeng Teng

Cell proliferation 54:e13055 PubMed33987885

2021

Activated mesangial cells induce glomerular endothelial cells proliferation in rat anti-Thy-1 nephritis through VEGFA/VEGFR2 and Angpt2/Tie2 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yinghua Zhao,Bo Fu,Pu Chen,Qinggang Li,Qing Ouyang,Chuyue Zhang,Guangyan Cai,Lingling Wu,Xiangmei Chen

The Journal of neuroscience : the official journal 40:1943-1955 PubMed31974206

2020

Elevated TRPV4 Levels Contribute to Endothelial Damage and Scarring in Experimental Spinal Cord Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Hemant Kumar,Chang Su Lim,Hyemin Choi,Hari Prasad Joshi,Kyoung-Tae Kim,Yong Ho Kim,Chul-Kyu Park,Hwan Myung Kim,In-Bo Han

Artificial cells, nanomedicine, and biotechnology 48:362-376 PubMed31899965

2020

Histological and functional outcomes in a rat model of hemisected spinal cord with sustained VEGF/NT-3 release from tissue-engineered grafts.

Applications

Unspecified application

Species

Unspecified reactive species

Zi-Xing Xu,Li-Qun Zhang,Yi-Nan Zhou,Xue-Min Chen,Wei-Hong Xu

Scientific reports 7:40156 PubMed28071761

2017

Plasma heme-induced renal toxicity is related to a capillary rarefaction.

Applications

Unspecified application

Species

Unspecified reactive species

Nahid Tabibzadeh,Céline Estournet,Sandrine Placier,Joëlle Perez,Héloïse Bilbault,Alexis Girshovich,Sophie Vandermeersch,Chantal Jouanneau,Emmanuel Letavernier,Nadjib Hammoudi,François Lionnet,Jean-Philippe Haymann

Nature communications 7:12061 PubMed27389904

2016

Wars2 is a determinant of angiogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Mao Wang,Patrick Sips,Ester Khin,Maxime Rotival,Ximing Sun,Rizwan Ahmed,Anissa Anindya Widjaja,Sebastian Schafer,Permeen Yusoff,Pervinder Kaur Choksi,Nicole Shi Jie Ko,Manvendra K Singh,David Epstein,Yuguang Guan,Josef Houštěk,Tomas Mracek,Hana Nuskova,Brittney Mikell,Jessie Tan,Francesco Pesce,Frantisek Kolar,Leonardo Bottolo,Massimiliano Mancini,Norbert Hubner,Michal Pravenec,Enrico Petretto,Calum MacRae,Stuart A Cook
View all publications
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