JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB106463

Anti-REEP3 antibody

Be the first to review this product! Submit a review

|

(4 Publications)

Rabbit Polyclonal REEP3 antibody. Suitable for WB and reacts with Rat samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human REEP3.

View Alternative Names

C10orf74, REEP3, Receptor expression-enhancing protein 3

1 Images
Western blot - Anti-REEP3 antibody (AB106463)
  • WB

Unknown

Western blot - Anti-REEP3 antibody (AB106463)

All lanes:

Western blot - Anti-REEP3 antibody (ab106463) at 1 µg/mL

Lane 1:

Rat heart tissue lysate at 15 µg

Lane 2:

Rat heart tissue lysate at 15 µg with immunizing peptide

Predicted band size: 29 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

WB

applications

Immunogen

Synthetic Peptide within Human REEP3. The exact immunogen used to generate this antibody is proprietary information.

Q6NUK4

Specificity

At least three isoforms of REEP3 are known to exist; ab106463 will detect all three.

style
left-column

Alternative Products

Primary Antibodies

AB241964

Anti-REEP3 antibody

Immunoprecipitation - Anti-REEP3 antibody (AB241964)

  • 0
  • 1

Complementary Products

Primary Antibodies

AB119714

Anti-CORO1B antibody

Immunocytochemistry/ Immunofluorescence - Anti-CORO1B antibody (AB119714)

  • 0
  • 0
Primary Antibodies

AB315013

Anti-VAPB antibody [EPR27026-50]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VAPB antibody [EPR27026-50] (AB315013)

  • 0
  • 0
Primary Antibodies

AB76286

Anti-beta III Tubulin (phospho S172) antibody

Western blot - Anti-beta III Tubulin (phospho S172) antibody (AB76286)

  • 4
  • 1
Primary Antibodies

AB70122

Anti-ARNT2 antibody

Western blot - Anti-ARNT2 antibody (AB70122)

  • 4
  • 1
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab106463 was purified by affinity chromatography via a peptide column.
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

REEP3 also known as Receptor Accessory Protein 3 plays an important role in mechanical processes within the cell. This protein assists in shaping the endoplasmic reticulum (ER) by facilitating the stacking and proper organization of the ER membranes. REEP3 has a molecular weight of approximately 28 kDa. Its expression is widespread but shows significant presence in neuronal tissues suggesting a specialized role in these cells.
Biological function summary

REEP3 manages the structural integrity of the endoplasmic reticulum by interacting with other proteins involved in ER morphology. It forms part of a complex that includes microtubule-associated proteins which link the ER to the cytoskeleton enabling proper cellular function. Through this interaction REEP3 supports the maintenance of cellular homeostasis and can influence processes such as protein synthesis and transport.

Pathways

Proteins like REEP3 contribute to ER shaping pathways and cellular stress response mechanisms. It acts alongside proteins like ATLASTIN and SEIPIN in the ER network assembly. Specifically it connects with pathways managing ER stress responses which are vital in adapting to and regulating changes in protein folding demand.

Aberrations in REEP3 function associate with conditions affecting the nervous system such as hereditary spastic paraplegia (HSP). Mutations in REEP3 can lead to defects in ER morphology contributing to neurodegenerative processes. The protein interacts with SPG4 and REEP1 linking it to cytoskeletal abnormalities observed in these disorders. Understanding REEP3's precise role in these pathologies offers potential avenues for therapeutic intervention.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes.
See full target information REEP3
style
left-column

Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Human molecular genetics 31:2779-2795 PubMed35348668

2022

Transverse endoplasmic reticulum expansion in hereditary spastic paraplegia corticospinal axons.

Applications

Unspecified application

Species

Unspecified reactive species

Peng-Peng Zhu,Hui-Fang Hung,Natalia Batchenkova,Jonathon Nixon-Abell,James Henderson,Pengli Zheng,Benoit Renvoisé,Song Pang,C Shan Xu,Stephan Saalfeld,Jan Funke,Yuxiang Xie,Fabian Svara,Harald F Hess,Craig Blackstone

Nature 601:132-138 PubMed34912111

2021

ER proteins decipher the tubulin code to regulate organelle distribution.

Applications

Unspecified application

Species

Unspecified reactive species

Pengli Zheng,Christopher J Obara,Ewa Szczesna,Jonathon Nixon-Abell,Kishore K Mahalingan,Antonina Roll-Mecak,Jennifer Lippincott-Schwartz,Craig Blackstone

Molecular biology of the cell 30:1377-1389 PubMed30995177

2019

REEP3 and REEP4 determine the tubular morphology of the endoplasmic reticulum during mitosis.

Applications

Unspecified application

Species

Unspecified reactive species

Darshan Kumar,Banafsheh Golchoubian,Ilya Belevich,Eija Jokitalo,Anne-Lore Schlaitz

ACS chemical neuroscience 10:2033-2044 PubMed30284806

2018

Chronic Social Isolation Stress during Peri-Adolescence Alters Presynaptic Dopamine Terminal Dynamics via Augmentation in Accumbal Dopamine Availability.

Applications

Unspecified application

Species

Unspecified reactive species

Anushree N Karkhanis,Amy C Leach,Jordan T Yorgason,Ayse Uneri,Samuel Barth,Farr Niere,Nancy J Alexander,Jeffrey L Weiner,Brian A McCool,Kimberly F Raab-Graham,Mark J Ferris,Sara R Jones
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com