Rabbit Polyclonal REEP3 antibody. Suitable for WB and reacts with Rat samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human REEP3.
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Publications
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- Human molecular genetics 31:2779-27952022Transverse endoplasmic reticulum expansion in hereditary spastic paraplegia corticospinal axons.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPeng-Peng Zhu,Hui-Fang Hung,Natalia Batchenkova,Jonathon Nixon-Abell,James Henderson,Pengli Zheng,Benoit Renvoisé,Song Pang,C Shan Xu,Stephan Saalfeld,Jan Funke,Yuxiang Xie,Fabian Svara,Harald F Hess,Craig BlackstonePubMed 35348668
- Nature 601:132-1382021ER proteins decipher the tubulin code to regulate organelle distribution.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPengli Zheng,Christopher J Obara,Ewa Szczesna,Jonathon Nixon-Abell,Kishore K Mahalingan,Antonina Roll-Mecak,Jennifer Lippincott-Schwartz,Craig BlackstonePubMed 34912111
- Molecular biology of the cell 30:1377-13892019REEP3 and REEP4 determine the tubular morphology of the endoplasmic reticulum during mitosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDarshan Kumar et. al.PubMed 30995177
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human REEP3. The exact immunogen used to generate this antibody is proprietary information. Database link Q6NUK4
Reactivity data
Select an application| WB | |
|---|---|
| Rat | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info 1.00000-2.00000 µg/mL | Notes - |
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Target data
Function
Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes.
Alternative names
C10orf74, REEP3, Receptor expression-enhancing protein 3
Recommended products
Rabbit Polyclonal REEP3 antibody. Suitable for WB and reacts with Rat samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human REEP3.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human REEP3. The exact immunogen used to generate this antibody is proprietary information. Database link Q6NUK4
- Purification technique
- Affinity purification Immunogen
- Specificity
At least three isoforms of REEP3 are known to exist; ab106463 will detect all three.
- Concentration
- Purification notes
ab106463 was purified by affinity chromatography via a peptide column.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
REEP3 also known as Receptor Accessory Protein 3 plays an important role in mechanical processes within the cell. This protein assists in shaping the endoplasmic reticulum (ER) by facilitating the stacking and proper organization of the ER membranes. REEP3 has a molecular weight of approximately 28 kDa. Its expression is widespread but shows significant presence in neuronal tissues suggesting a specialized role in these cells.
- Biological function summary
REEP3 manages the structural integrity of the endoplasmic reticulum by interacting with other proteins involved in ER morphology. It forms part of a complex that includes microtubule-associated proteins which link the ER to the cytoskeleton enabling proper cellular function. Through this interaction REEP3 supports the maintenance of cellular homeostasis and can influence processes such as protein synthesis and transport.
- Pathways
Proteins like REEP3 contribute to ER shaping pathways and cellular stress response mechanisms. It acts alongside proteins like ATLASTIN and SEIPIN in the ER network assembly. Specifically it connects with pathways managing ER stress responses which are vital in adapting to and regulating changes in protein folding demand.
- Associated diseases and disorders
Aberrations in REEP3 function associate with conditions affecting the nervous system such as hereditary spastic paraplegia (HSP). Mutations in REEP3 can lead to defects in ER morphology contributing to neurodegenerative processes. The protein interacts with SPG4 and REEP1 linking it to cytoskeletal abnormalities observed in these disorders. Understanding REEP3's precise role in these pathologies offers potential avenues for therapeutic intervention.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-REEP3 antibody (ab106463)
All lanes: Western blot - Anti-REEP3 antibody (ab106463) at 1 µg/mL
Lane 1: Rat heart tissue lysate at 15 µg
Lane 2: Rat heart tissue lysate at 15 µg with immunizing peptide
Predicted band size: 29 kDa
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