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AB167405

Anti-REEP5 antibody [EPR11114(B)]

4

(3 Reviews)

|

(2 Publications)

Rabbit Recombinant Monoclonal REEP5 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications.

View Alternative Names

C5orf18, DP1, TB2, REEP5, Receptor expression-enhancing protein 5, Polyposis locus protein 1, Protein TB2

1 Images
Western blot - Anti-REEP5 antibody [EPR11114(B)] (AB167405)
  • WB

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Western blot - Anti-REEP5 antibody [EPR11114(B)] (AB167405)

All lanes:

Western blot - Anti-REEP5 antibody [EPR11114(B)] (ab167405) at 1/1000 dilution

Lane 1:

MCF-7 cell lysate at 10 µg

Lane 2:

K652 cell lysate at 10 µg

Lane 3:

Jurkat cell lysate at 10 µg

Lane 4:

HeLa cell lysate at 10 µg

Predicted band size: 21 kDa

false

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR11114(B)

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

REEP5 also known as Receptor Expression Enhancing Protein 5 facilitates cell machinery in organizing and shaping the membranes of the endoplasmic reticulum. This protein has a molecular mass of approximately 22 kDa. REEP5 is expressed abundantly in the heart and skeletal muscle though it also exists in other tissues at lower levels. The protein is known to assist in membrane topology which is essential for maintaining proper endoplasmic reticulum morphology and function.
Biological function summary

REEP5 supports endoplasmic reticulum tubule formation helping maintain the high curvature structure of the organelle. It becomes part of a larger protein complex contributing to the development and maintenance of the fine network structure typical of the endoplasmic reticulum. By doing so REEP5 plays a role in the spatial organization of the cellular environment ensuring the proper segregation and function of cellular components.

Pathways

REEP5 actively participates in cellular stress response and the unfolded protein response pathway. This pathway involves proteins such as IRE1 and PERK which sensor and manage cellular stress by regulating protein folding and assisting in maintaining homeostasis. REEP5 provides structural regulation in these pathways impacting protein synthesis and secretion processes which are essential for adapting to cellular demands and stress.

REEP5 has been implicated in heart conditions particularly dilated cardiomyopathy. This disorder involves the heart muscle becoming weakened and enlarged affecting its ability to pump blood efficiently. Mutations or dysregulation of REEP5 impact its interaction with proteins like ATL1 and ATL2 which are involved in membrane fusion processes. Additionally REEP5 has shown associations with neurodegenerative conditions indicating its wider significance in maintaining cellular health and function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays an essential role in heart function and development by regulating the organization and function of the sarcoplasmic reticulum in cardiomyocytes.
See full target information REEP5
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cell cycle (Georgetown, Tex.) 22:1900-1920 PubMed37603831

2023

is a key factor regulating reticulophagy-mediated ferroptosis in hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Tao Bi,Qianqian Lu,Xiaohong Pan,Fenglin Dong,Yejia Hu,Zongzhen Xu,Peng Xiu,Zhiqian Liu,Jie Li

Cell 186:327-345.e28 PubMed36603581

2023

Functional partitioning of transcriptional regulators by patterned charge blocks.

Applications

Unspecified application

Species

Unspecified reactive species

Heankel Lyons,Reshma T Veettil,Prashant Pradhan,Christy Fornero,Nancy De La Cruz,Keiichi Ito,Mikayla Eppert,Robert G Roeder,Benjamin R Sabari
View all publications
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Product promise

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