Rabbit Polyclonal REEP6 antibody. Suitable for IHC-P, ICC, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human REEP6 aa 1-50.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human REEP6 aa 1-50. The exact immunogen used to generate this antibody is proprietary information. Database link Q96HR9
Reactivity data
Select an application| IHC-P | ICC | WB | |
|---|---|---|---|
| Human | Tested | Tested | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/1000.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ICC
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.25000-2.00000 µg/mL | Notes - |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.04000-0.40000 µg/mL | Notes - |
Target data
Function
Required for correct function and survival of retinal photoreceptors (PubMed:27889058). Required for retinal development (By similarity). In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis (By similarity). May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane (By similarity).
Alternative names
C19orf32, DP1L1, REEP6, Receptor expression-enhancing protein 6, Polyposis locus protein 1-like 1
Recommended products
Rabbit Polyclonal REEP6 antibody. Suitable for IHC-P, ICC, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human REEP6 aa 1-50.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human REEP6 aa 1-50. The exact immunogen used to generate this antibody is proprietary information. Database link Q96HR9
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
REEP6 also known as Receptor Expression Enhancing Protein 6 is a protein with a molecular mass of approximately 27 kDa. Its main mechanical role is to assist with the proper folding and expression of receptor proteins in the endoplasmic reticulum (ER). REEP6 is strongly expressed in retinal cells but it may also be present in lower levels in other tissues. By interacting with newly synthesized proteins REEP6 helps in their stabilization and transport to the cell surface.
- Biological function summary
The REEP6 protein supports sensory neuron function by regulating receptor proteins critical for processing sensory inputs. It does this as part of protein complexes within ER membranes where it influences the trafficking of G protein-coupled receptors (GPCRs) specifically involved in visual photoreception. In the context of the retina REEP6 actions enable photoreceptors to respond correctly to light which is important for vision.
- Pathways
Research identifies REEP6 as integral to cellular mechanisms related to protein processing and trafficking pathways. It plays a role along with proteins such as GPrin1 and Sec24C in the phototransduction pathway which converts light stimuli into visual signals. These pathways control how proteins are sorted and delivered to their destinations affecting overall cell communication and homeostasis.
- Associated diseases and disorders
Mutations in REEP6 are linked to retinitis pigmentosa a degenerative eye condition leading to vision loss. This disorder affects photoreceptor function and is connected to rhodopsin protein deficiencies which are common in patients with this type of retinal disorder. Variants in REEP6 can also affect its function resulting in altered receptor expression that contributes to disease progression.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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6 product images
Immunocytochemistry - Anti-REEP6 antibody (ab204341)
Immunocytochemistry analysis of HepG2 (human liver hepatocellular carcinoma cell line) cells labelling REEP6 with ab204341 at 2 μg/mL.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-REEP6 antibody (ab204341)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human testis tissue labelling REEP6 with ab204341 at 1/500 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.
Western blot - Anti-REEP6 antibody (ab204341)
All lanes: Western blot - Anti-REEP6 antibody (ab204341) at 1/500 dilution
Lane 1: RT-4 cell lysate
Lane 2: U-251 MG cell lysate
Lane 3: Human plasma
Lane 4: Human liver tissue lysate
Developed using the ECL technique.
Predicted band size: 20 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-REEP6 antibody (ab204341)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human small intestine tissue labelling REEP6 with ab204341 at 1/500 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-REEP6 antibody (ab204341)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human liver tissue labelling REEP6 with ab204341 at 1/500 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-REEP6 antibody (ab204341)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human skeletal muscle tissue labelling REEP6 with ab204341 at 1/500 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.
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